| Literature DB >> 23548124 |
Zhou Jiang1, Yuhui Wang, Xiaoyun Zhang, Tao Peng, Yun Lu, Jianchun Leng, Quan Xie.
Abstract
To examine the preventive and therapeutic effects of ginsenoside Rb1 for neural injury during cerebral infarction, we used a middle cerebral artery occlusion (MCAO) model in rats to investigate the effects of ginsenoside Rb1 with Edaravone as a control. Ginsenoside Rb1 was given to the rats by intragastric administration either before or after the MCAO surgery to study its preventive and therapeutic effects. Ginsenoside Rb1-treated rats had a smaller infarct volume than the positive control. Interleukin-1 (IL-1), brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), neurofilament (NF) and growth associated protein-43 (GAP-43) were measured to determine brain damage and the recovery of nerves. These findings suggest that ginsenoside Rb1 has neuroprotective effects in rats, and the protection efficiency is higher than Edaravone. The protective mechanism is different from Edaravone. The preventive ability of ginsenoside Rb1 is higher than its repair ability in neuroprotection in vivo.Entities:
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Year: 2013 PMID： 23548124 DOI： 10.1142/S0192415X13500250
Source DB: PubMed Journal: Am J Chin Med ISSN： 0192-415X Impact factor: 4.667