| Literature DB >> 23548074 |
Mukulesh Mondal1, Han-Jen Ho, Nicholas J Peraino, Melanie A Gary, Kraig A Wheeler, Nessan J Kerrigan.
Abstract
In this paper, a novel approach to γ-lactones from the reaction of sulfoxonium ylides, aldehydes, and ketenes is described. The new ylide-based method provides access to γ-lactones from disubstituted ketenes, in good yields, and with good diastereoselectivity favoring the trans-diastereomer (11 examples with dr ≥ 82:18, dr up to 92:8).Entities:
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Year: 2013 PMID： 23548074 DOI： 10.1021/jo4003213
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354