Literature DB >> 23547954

Copper-catalyzed aerobic C(sp2)-H functionalization for C-N bond formation: synthesis of pyrazoles and indazoles.

Xianwei Li1, Li He, Huoji Chen, Wanqing Wu, Huanfeng Jiang.   

Abstract

A simple, practical, and highly efficient synthesis of pyrazoles and indazoles via copper-catalyzed direct aerobic oxidative C(sp(2))-H amination has been reported herein. This process tolerated a variety of functional groups under mild conditions. Further diversification of pyrazoles was also investigated, which provided its potential for drug discovery.

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Year:  2013        PMID： 23547954     DOI： 10.1021/jo400162d

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  12 in total

1.  Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles.

Authors:  Vunnam Venkateswarlu; Jaspreet Kour; K A Aravinda Kumar; Praveen Kumar Verma; G Lakshma Reddy; Yaseen Hussain; Aliya Tabassum; Shilpi Balgotra; Sorav Gupta; Abhinandan D Hudwekar; Ram A Vishwakarma; Sanghapal D Sawant
Journal:  RSC Adv       Date:  2018-07-24       Impact factor: 4.036

2.  Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination.

Authors:  Areum Park; Kyu-Sung Jeong; Hyuk Lee; Hyunwoo Kim
Journal:  ACS Omega       Date:  2021-02-23

3.  Rh(iii)-catalyzed double C-H activation of aldehyde hydrazones: a route for functionalized 1H-indazole synthesis.

Authors:  Pan Xu; Guoqiang Wang; Zhongkai Wu; Shuhua Li; Chengjian Zhu
Journal:  Chem Sci       Date:  2016-10-07       Impact factor: 9.825

4.  Synthesis, Crystal Structure, and Supramolecular Understanding of 1,3,5-Tris(1-phenyl-1H-pyrazol-5-yl)benzenes.

Authors:  Marcos A P Martins; Alexandre R Meyer; Paulo R S Salbego; Daniel M Dos Santos; Guilherme A de Moraes; Helio G Bonacorso; Nilo Zanatta; Clarissa P Frizzo; Manfredo Hörner
Journal:  Molecules       Date:  2017-12-22       Impact factor: 4.411

Review 5.  A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications.

Authors:  Nagaraju Kerru; Lalitha Gummidi; Suresh Maddila; Kranthi Kumar Gangu; Sreekantha B Jonnalagadda
Journal:  Molecules       Date:  2020-04-20       Impact factor: 4.411

Review 6.  Styrylpyrazoles: Properties, Synthesis and Transformations.

Authors:  Pedro M O Gomes; Pedro M S Ouro; Artur M S Silva; Vera L M Silva
Journal:  Molecules       Date:  2020-12-12       Impact factor: 4.411

7.  Construction of multi-substituted pyrazoles via potassium carbonate-mediated [3 + 2] cycloaddition of in situ generated nitrile imines with cinnamic aldehydes.

Authors:  Mei-Mei Li; Hui Huang; Wanrong Tian; Yiru Pu; Chaozheng Zhang; Jirui Yang; Qing Ren; Feiyan Tao; Yun Deng; Jun Lu
Journal:  RSC Adv       Date:  2022-04-29       Impact factor: 4.036

8.  Polyoxometalate-Supported Copper(I)-Pyrazole Complex: Unusual Stability, Geometrical Isomers, Organic Transformation, and Computation.

Authors:  Neeraj Kumar Mishra; Deepak Bansal; Sabbani Supriya
Journal:  ACS Omega       Date:  2022-08-22

Review 9.  Recent Strategies in Transition-Metal-Catalyzed Sequential C-H Activation/Annulation for One-Step Construction of Functionalized Indazole Derivatives.

Authors:  Pezhman Shiri; Atefeh Roosta; Wim Dehaen; Ali Mohammad Amani
Journal:  Molecules       Date:  2022-08-03       Impact factor: 4.927

10.  Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies.

Authors:  Islam H El Azab; Rania B Bakr; Nadia A A Elkanzi
Journal:  Molecules       Date:  2021-05-22       Impact factor: 4.411
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