Literature DB >> 23547874

Synthesis of novel steroid derivatives derived from dehydroepiandrosterone as potential anticancer agents.

Shaoyong Ke1, Yanhong Wei, Liqiao Shi, Qingyu Yang, Ziwen Yang.   

Abstract

A series of dehydroepiandrosterone derivatives containing dihydrazone unit was synthesized via a convenient condensation procedure, and which were evaluated for their potential anticancer activities. The preliminary assays indicated that some of the newly synthesized compounds exhibited good antitumor activities against human hepatocellular liver carcinoma (HepG2), heptoma (Huh-7), gastric cancer (BGC-823) and breast adenocarcinoma (MCF-7) cell lines compared with 5-fluorouracil (5-FU), which might be considered as promising lead scaffold for further design and synthesis of potential anticancer agents.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23547874     DOI： 10.2174/18715206113139990323

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  5 in total

1.  Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men.

Authors:  Jessica L Petrick; Paula L Hyland; Patrick Caron; Roni T Falk; Ruth M Pfeiffer; Sanford M Dawsey; Christian C Abnet; Philip R Taylor; Stephanie J Weinstein; Demetrius Albanes; Neal D Freedman; Susan M Gapstur; Gary Bradwin; Chantal Guillemette; Peter T Campbell; Michael B Cook
Journal:  J Natl Cancer Inst       Date:  2019-01-01       Impact factor: 13.506

2.  Steroidal[17,16-d]pyrimidines derived from dehydroepiandrosterone: A convenient synthesis, antiproliferation activity, structure-activity relationships, and role of heterocyclic moiety.

Authors:  Shaoyong Ke; Liqiao Shi; Zhigang Zhang; Ziwen Yang
Journal:  Sci Rep       Date:  2017-03-14       Impact factor: 4.379

3.  Peptidomimetics Based On Dehydroepiandrosterone Scaffold: Synthesis, Antiproliferation Activity, Structure-Activity Relationship, and Mechanisms.

Authors:  Xiaohui Wang; Haihuan Su; Wenda Wang; Changshui Chen; Xiufang Cao
Journal:  Sci Rep       Date:  2016-09-02       Impact factor: 4.379

4.  Screening of novel synthetic derivatives of dehydroepiandrosterone for antivirals against flaviviruses infections.

Authors:  Muhammad Imran; Luping Zhang; Bohan Zheng; Zikai Zhao; Dengyuan Zhou; Shengfeng Wan; Zheng Chen; Hongyu Duan; Qiuyan Li; Xueqin Liu; Shengbo Cao; Shaoyong Ke; Jing Ye
Journal:  Virol Sin       Date:  2022-01-18       Impact factor: 4.327

5.  Novel Steroidal 5α,8α-Endoperoxide Derivatives with Semicarbazone/Thiosemicarbazone Side-chain as Apoptotic Inducers through an Intrinsic Apoptosis Pathway: Design, Synthesis and Biological Studies.

Authors:  Liwei Ma; Haijun Wang; Jing Wang; Lei Liu; Song Zhang; Ming Bu
Journal:  Molecules       Date:  2020-03-07       Impact factor: 4.411
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.