AIM: Expression profiles indicate that miR-122 is specifically and abundantly expressed in liver. This study sought to determine miR-122 plasma concentrations in 15 apparently healthy subjects and 30 patients with liver disease, and clarify whether plasma miR-122 correlates with ALT. MATERIALS & METHODS: miR-122 was measured by quantitative PCR in healthy volunteers and patients with liver disease. RESULTS: ALT was increased in two out of 15 (13%) apparently healthy subjects and 17 out of 30 (57%) liver disease patients. In healthy subjects, median miR-122 plasma concentration was 51.7 copies/20 pg RNA (range 16.0-312.0). In liver disease patients, median miR-122 was significantly elevated to 202.3 copies/20 pg RNA (range 20.9-1160.0; Mann-Whitney test between median concentrations; p = 0.0016). CONCLUSION: This small proof-of-principle study suggests that miR-122 may be a potential plasma biomarker of liver damage.
AIM: Expression profiles indicate that miR-122 is specifically and abundantly expressed in liver. This study sought to determine miR-122 plasma concentrations in 15 apparently healthy subjects and 30 patients with liver disease, and clarify whether plasma miR-122 correlates with ALT. MATERIALS & METHODS:miR-122 was measured by quantitative PCR in healthy volunteers and patients with liver disease. RESULTS: ALT was increased in two out of 15 (13%) apparently healthy subjects and 17 out of 30 (57%) liver diseasepatients. In healthy subjects, median miR-122 plasma concentration was 51.7 copies/20 pg RNA (range 16.0-312.0). In liver diseasepatients, median miR-122 was significantly elevated to 202.3 copies/20 pg RNA (range 20.9-1160.0; Mann-Whitney test between median concentrations; p = 0.0016). CONCLUSION: This small proof-of-principle study suggests that miR-122 may be a potential plasma biomarker of liver damage.
Authors: Pierre R Bushel; Florian Caiment; Han Wu; Raegan O'Lone; Frank Day; John Calley; Aaron Smith; Jianying Li; Alison H Harrill Journal: RNA Biol Date: 2020-02-12 Impact factor: 4.652
Authors: Xi Yang; William F Salminen; Qiang Shi; James Greenhaw; Pritmohinder S Gill; Sudeepa Bhattacharyya; Richard D Beger; Donna L Mendrick; William B Mattes; Laura P James Journal: Toxicol Appl Pharmacol Date: 2015-02-21 Impact factor: 4.219
Authors: Jonathan Rice; Henry Roberts; James Burton; Jianmin Pan; Vanessa States; Shesh N Rai; Susan Galandiuk Journal: PLoS One Date: 2015-04-08 Impact factor: 3.240