Literature DB >> 23546688

Therapeutic potential of SIGIRR in systemic lupus erythematosus.

Chao Wang1, Chen-Chen Feng, Hai-Feng Pan, De-Guang Wang, Dong-Qing Ye.   

Abstract

Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. Different from other typical IL-1R superfamily members, SIGIRR seems to exert negatively modulates in immune responses. Several previous studies demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, such as intestinal inflammation, rheumatoid arthritis and psoriatic arthritis. Recent work has explored the role of SIGIRR in systemic lupus erythematosus (SLE), for example, the role of SIGIRR protects the mice from hydrocarbon oil-induced lupus has been reported. These results indicate that SIGIRR may represent a novel target for the treatment of SLE. In this review, we will discuss the SIGIRR and the therapeutic potential of modulating the pathway in SLE.

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Year:  2013        PMID： 23546688     DOI： 10.1007/s00296-013-2733-0

Source DB:  PubMed          Journal:  Rheumatol Int        ISSN： 0172-8172            Impact factor:   2.631


  28 in total

1.  SIGIRR puts the brakes on Toll-like receptors.

Authors:  Luke A J O'Neill
Journal:  Nat Immunol       Date:  2003-09       Impact factor: 25.606

Review 2.  Neuropsychiatric lupus: clinical and imaging aspects.

Authors:  Robin L Brey
Journal:  Bull NYU Hosp Jt Dis       Date:  2007

Review 3.  Th1/Th2 balance of SLE patients with lupus nephritis.

Authors:  Hitoshi Nakashima; Mitsuteru Akahoshi; Kohsuke Masutani
Journal:  Rinsho Byori       Date:  2006-07

4.  IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.

Authors:  Ceire Costelloe; Melanie Watson; Aine Murphy; Keith McQuillan; Christine Loscher; Michelle E Armstrong; Cecilia Garlanda; Alberto Mantovani; Luke A J O'Neill; Kingston H G Mills; Marina A Lynch
Journal:  J Neurochem       Date:  2008-02-18       Impact factor: 5.372

Review 5.  TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization.

Authors:  Cecilia Garlanda; Hans-Joachim Anders; Alberto Mantovani
Journal:  Trends Immunol       Date:  2009-08-21       Impact factor: 16.687

6.  Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.

Authors:  Nadia Polentarutti; Giselle Penton Rol; Marta Muzio; Daniela Bosisio; Marco Camnasio; Federica Riva; Carla Zoja; Ariela Benigni; Susanna Tomasoni; Annunciata Vecchi; Cecilia Garlanda; Alberto Mantovani
Journal:  Eur Cytokine Netw       Date:  2003 Oct-Dec       Impact factor: 2.737

7.  The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.

Authors:  Muhammet F Gulen; Zizhen Kang; Katarzyna Bulek; Wan Youzhong; Tae Whan Kim; Yi Chen; Cengiz Z Altuntas; Kristian Sass Bak-Jensen; Mandy J McGeachy; Jeong-Su Do; Hui Xiao; Greg M Delgoffe; Booki Min; Jonathan D Powell; Vincent K Tuohy; Daniel J Cua; Xiaoxia Li
Journal:  Immunity       Date:  2010-01-07       Impact factor: 31.745

8.  Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family.

Authors:  Cecilia Garlanda; Federica Riva; Tania Veliz; Nadia Polentarutti; Fabio Pasqualini; Enrico Radaelli; Marina Sironi; Manuela Nebuloni; Elisabetta Omodeo Zorini; Eugenio Scanziani; Alberto Mantovani
Journal:  Cancer Res       Date:  2007-07-01       Impact factor: 12.701

9.  Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.

Authors:  Silvia Bozza; Teresa Zelante; Silvia Moretti; Pierluigi Bonifazi; Antonella DeLuca; Carmen D'Angelo; Gloria Giovannini; Cecilia Garlanda; Louis Boon; Francesco Bistoni; Paolo Puccetti; Alberto Mantovani; Luigina Romani
Journal:  J Immunol       Date:  2008-03-15       Impact factor: 5.422

10.  Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens.

Authors:  Maciej Lech; Onkar P Kulkarni; Stephanie Pfeiffer; Emina Savarese; Anne Krug; Cecilia Garlanda; Alberto Mantovani; Hans-Joachim Anders
Journal:  J Exp Med       Date:  2008-07-21       Impact factor: 14.307
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  4 in total

1.  Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity.

Authors:  Jian-Ping Xiao; Dao-Yang Wang; Xue-Rong Wang; Liang Yuan; Li Hao; De-Guang Wang
Journal:  Biomed Rep       Date:  2018-08-03

Review 2.  Potential roles of nucleotide-binding oligomerization domain 2 in the pathogenesis of systemic lupus erythematosus.

Authors:  Jing Li; Song Wu; Ming-Rui Wang; Ting-Ting Wang; Bai-Kun Li; Ji-Min Zhu
Journal:  Rheumatol Int       Date:  2014-03-06       Impact factor: 2.631

3.  Emerging role of SIGIRR rs7396562(T/G) polymorphism in systemic lupus erythematosus in a Chinese population.

Authors:  Yan Zhu; De-Guang Wang; Xiao-Ke Yang; Sha-Sha Tao; Qing Huang; Hai-Feng Pan; Chen-Chen Feng; Dong-Qing Ye
Journal:  Inflammation       Date:  2014-10       Impact factor: 4.092

4.  Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis.

Authors:  Xiaoke Yang; Mingyue Zhang; Shengqian Xu; Haifeng Pan; Ruixue Leng; Zongwen Shuai
Journal:  Biomed Res Int       Date:  2021-05-07       Impact factor: 3.411
  4 in total

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