BACKGROUND: This study evaluates which cognitive measure is best for predicting incident dementia in a population-based random sample of Chinese older adults without dementia over a five-year period. METHODS: A total of 787 community-dwelling Chinese older adults without dementia in Hong Kong were assessed at baseline (T0), at two years (T1), and at five years (T2). RESULTS: The annual conversion rate to dementia was 1.6% and 6.3% for baseline normal participants and baseline mild cognitive impairment (MCI) participants, respectively. The Cantonese version of Mini-mental State Examination (CMMSE) scores declined significantly over time. In participants who progressed to dementia, Category Verbal Fluency Test (CVFT) scores dropped significantly from T0 to T1. A 1-SD drop of either CMMSE or CVFT in two years predicted dementia at five years with 91.5% sensitivity and 62.0% specificity. A stable CMMSE and CVFT at two years predicted a 91% chance of not progressing to clinical dementia at five years. CONCLUSION: In this community sample of Chinese older adults, a decline in cognitive screening tests in short term (two years) offered useful information in predicting dementia conversion over a longer period.
BACKGROUND: This study evaluates which cognitive measure is best for predicting incident dementia in a population-based random sample of Chinese older adults without dementia over a five-year period. METHODS: A total of 787 community-dwelling Chinese older adults without dementia in Hong Kong were assessed at baseline (T0), at two years (T1), and at five years (T2). RESULTS: The annual conversion rate to dementia was 1.6% and 6.3% for baseline normal participants and baseline mild cognitive impairment (MCI) participants, respectively. The Cantonese version of Mini-mental State Examination (CMMSE) scores declined significantly over time. In participants who progressed to dementia, Category Verbal Fluency Test (CVFT) scores dropped significantly from T0 to T1. A 1-SD drop of either CMMSE or CVFT in two years predicted dementia at five years with 91.5% sensitivity and 62.0% specificity. A stable CMMSE and CVFT at two years predicted a 91% chance of not progressing to clinical dementia at five years. CONCLUSION: In this community sample of Chinese older adults, a decline in cognitive screening tests in short term (two years) offered useful information in predicting dementia conversion over a longer period.
Authors: Keith H Radler; Maria Anna Zdrodowska; Hollie Dowd; Tess E K Cersonsky; Edward D Huey; Stephanie Cosentino; Elan D Louis Journal: Parkinsonism Relat Disord Date: 2020-04-15 Impact factor: 4.891
Authors: Ingrid Arevalo-Rodriguez; Nadja Smailagic; Marta Roqué I Figuls; Agustín Ciapponi; Erick Sanchez-Perez; Antri Giannakou; Olga L Pedraza; Xavier Bonfill Cosp; Sarah Cullum Journal: Cochrane Database Syst Rev Date: 2015-03-05
Authors: J Santabárbara; R Lopez-Anton; P Gracia-García; C De-la-Cámara; D Vaquero-Puyuelo; E Lobo; G Marcos; L Salvador-Carulla; T Palomo; N Sartorius; A Lobo Journal: Epidemiol Psychiatr Sci Date: 2015-10-15 Impact factor: 6.892
Authors: Darren M Lipnicki; John D Crawford; Rajib Dutta; Anbupalam Thalamuthu; Nicole A Kochan; Gavin Andrews; M Fernanda Lima-Costa; Erico Castro-Costa; Carol Brayne; Fiona E Matthews; Blossom C M Stephan; Richard B Lipton; Mindy J Katz; Karen Ritchie; Jacqueline Scali; Marie-Laure Ancelin; Nikolaos Scarmeas; Mary Yannakoulia; Efthimios Dardiotis; Linda C W Lam; Candy H Y Wong; Ada W T Fung; Antonio Guaita; Roberta Vaccaro; Annalisa Davin; Ki Woong Kim; Ji Won Han; Tae Hui Kim; Kaarin J Anstey; Nicolas Cherbuin; Peter Butterworth; Marcia Scazufca; Shuzo Kumagai; Sanmei Chen; Kenji Narazaki; Tze Pin Ng; Qi Gao; Simone Reppermund; Henry Brodaty; Antonio Lobo; Raúl Lopez-Anton; Javier Santabárbara; Perminder S Sachdev Journal: PLoS Med Date: 2017-03-21 Impact factor: 11.069
Authors: Darren M Lipnicki; Steve R Makkar; John D Crawford; Anbupalam Thalamuthu; Nicole A Kochan; Maria Fernanda Lima-Costa; Erico Castro-Costa; Cleusa Pinheiro Ferri; Carol Brayne; Blossom Stephan; Juan J Llibre-Rodriguez; Jorge J Llibre-Guerra; Adolfo J Valhuerdi-Cepero; Richard B Lipton; Mindy J Katz; Carol A Derby; Karen Ritchie; Marie-Laure Ancelin; Isabelle Carrière; Nikolaos Scarmeas; Mary Yannakoulia; Georgios M Hadjigeorgiou; Linda Lam; Wai-Chi Chan; Ada Fung; Antonio Guaita; Roberta Vaccaro; Annalisa Davin; Ki Woong Kim; Ji Won Han; Seung Wan Suh; Steffi G Riedel-Heller; Susanne Roehr; Alexander Pabst; Martin van Boxtel; Sebastian Köhler; Kay Deckers; Mary Ganguli; Erin P Jacobsen; Tiffany F Hughes; Kaarin J Anstey; Nicolas Cherbuin; Mary N Haan; Allison E Aiello; Kristina Dang; Shuzo Kumagai; Tao Chen; Kenji Narazaki; Tze Pin Ng; Qi Gao; Ma Shwe Zin Nyunt; Marcia Scazufca; Henry Brodaty; Katya Numbers; Julian N Trollor; Kenichi Meguro; Satoshi Yamaguchi; Hiroshi Ishii; Antonio Lobo; Raul Lopez-Anton; Javier Santabárbara; Yvonne Leung; Jessica W Lo; Gordana Popovic; Perminder S Sachdev Journal: PLoS Med Date: 2019-07-23 Impact factor: 11.069
Authors: Perminder S Sachdev; Darren M Lipnicki; Nicole A Kochan; John D Crawford; Anbupalam Thalamuthu; Gavin Andrews; Carol Brayne; Fiona E Matthews; Blossom C M Stephan; Richard B Lipton; Mindy J Katz; Karen Ritchie; Isabelle Carrière; Marie-Laure Ancelin; Linda C W Lam; Candy H Y Wong; Ada W T Fung; Antonio Guaita; Roberta Vaccaro; Annalisa Davin; Mary Ganguli; Hiroko Dodge; Tiffany Hughes; Kaarin J Anstey; Nicolas Cherbuin; Peter Butterworth; Tze Pin Ng; Qi Gao; Simone Reppermund; Henry Brodaty; Nicole Schupf; Jennifer Manly; Yaakov Stern; Antonio Lobo; Raúl Lopez-Anton; Javier Santabárbara Journal: PLoS One Date: 2015-11-05 Impact factor: 3.240
Authors: Perminder S Sachdev; Darren M Lipnicki; Nicole A Kochan; John D Crawford; Kenneth Rockwood; Shifu Xiao; Juan Li; Xia Li; Carol Brayne; Fiona E Matthews; Blossom C M Stephan; Richard B Lipton; Mindy J Katz; Karen Ritchie; Isabelle Carrière; Marie-Laure Ancelin; Sudha Seshadri; Rhoda Au; Alexa S Beiser; Linda C W Lam; Candy H Y Wong; Ada W T Fung; Ki Woong Kim; Ji Won Han; Tae Hui Kim; Ronald C Petersen; Rosebud O Roberts; Michelle M Mielke; Mary Ganguli; Hiroko H Dodge; Tiffany Hughes; Kaarin J Anstey; Nicolas Cherbuin; Peter Butterworth; Tze Pin Ng; Qi Gao; Simone Reppermund; Henry Brodaty; Kenichi Meguro; Nicole Schupf; Jennifer Manly; Yaakov Stern; Antonio Lobo; Raúl Lopez-Anton; Javier Santabárbara Journal: BMC Neurol Date: 2013-11-06 Impact factor: 2.474