OBJECTIVE: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. METHOD: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). RESULTS: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT=25), overall death (NNT=34), and neonatal sepsis (NNT=34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p<0.001) and hospitalization time (p<0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC. CONCLUSION: In premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications.
OBJECTIVE: To elucidate the benefits of using probiotics in the prevention of necrotizing enterocolitis (NEC) and its complications in preterm newborns. METHOD: This was a systematic review of randomized controlled trials, which included studies retrieved from three databases (MEDLINE, Embase, and LILACS), using a combination of the terms (necrotizing enterocolitis) AND (probiotics). RESULTS: 11 randomized trials were included, totaling 2,887 patients, 1,431 in the probiotic group and 1,456 in the control group. There was a reduction in the incidence of NEC (NNT=25), overall death (NNT=34), and neonatal sepsis (NNT=34) in the probiotic group compared to the control group. Patients that received probiotic supplementation had lower food reintroduction time (p<0.001) and hospitalization time (p<0.001) when compared to those not receiving probiotics. There was no difference in mortality caused by NEC. CONCLUSION: In premature newborns, the use of probiotics is effective as a prophylaxis for NEC and its complications.
Authors: Michael L Jensen; Thomas Thymann; Malene S Cilieborg; Mikkel Lykke; Lars Mølbak; Bent B Jensen; Mette Schmidt; Denise Kelly; Imke Mulder; Douglas G Burrin; Per T Sangild Journal: Am J Physiol Gastrointest Liver Physiol Date: 2013-10-24 Impact factor: 4.052
Authors: Do-Yeon Cho; Daniel Skinner; Dong Jin Lim; John G Mclemore; Connor G Koch; Shaoyan Zhang; William E Swords; Ryan Hunter; David K Crossman; Michael R Crowley; Jessica W Grayson; Steven M Rowe; Bradford A Woodworth Journal: Int Forum Allergy Rhinol Date: 2020-01-10 Impact factor: 3.858
Authors: Bryon Petschow; Joël Doré; Patricia Hibberd; Timothy Dinan; Gregor Reid; Martin Blaser; Patrice D Cani; Fred H Degnan; Jane Foster; Glenn Gibson; John Hutton; Todd R Klaenhammer; Ruth Ley; Max Nieuwdorp; Bruno Pot; David Relman; Andrew Serazin; Mary Ellen Sanders Journal: Ann N Y Acad Sci Date: 2013-11-22 Impact factor: 5.691