| Literature DB >> 2354420 |
C Welter1, W Henn, B Theisinger, H Fischer, K D Zang, N Blin.
Abstract
The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by densitometry was about 10-fold, a rearrangement within the coding region and an enhanced gene activity of c-myb were noted. The observation of c-myb oncogene amplification and activity in glioblastoma cell lines presents the first report of this effect in human brain tumor cells.Entities:
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Year: 1990 PMID： 2354420 DOI： 10.1016/0304-3835(90)90077-b
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679