Literature DB >> 23543950

Suppression of immune responses in pigs by nonstructural protein 1 of porcine reproductive and respiratory syndrome virus.

Yefei Zhou1, Juan Bai, Yufeng Li, Xinglong Wang, Xianwei Wang, Ping Jiang.   

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is characterized by a delayed and defective adaptive immune response. The viral nonstructural protein 1 (NSP1) of the PRRS virus (PRRSV) is able to suppress the type I interferon (IFN) response in vitro. In this study, recombinant adenoviruses (rAds) expressing NSP1 (rAd-NSP1), glycoprotein 5 (GP5) (rAd-GP5), and the NSP1-GP5 fusion protein (rAd-NSP1-GP5) were constructed, and the effect of NSP1 on immune responses was investigated in pigs. Pigs inoculated with rAd-NSP1 or rAd-NSP1-GP5 had significantly lower levels of IFN-γ and higher levels of the immunosuppressive cytokine IL-10 than pigs inoculated with rAd-GP5, wild-type adenovirus, or cell culture medium alone. The antibody response to vaccination against classic swine fever virus (CSFV) was significantly decreased by inoculation of NSP1 7 d after CSFV vaccination in pigs. Thus, NSP1-mediated immune suppression may play an important role in PRRSV pathogenesis.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23543950      PMCID： PMC3460603     

Source DB:  PubMed          Journal:  Can J Vet Res        ISSN： 0830-9000            Impact factor:   1.310


  44 in total

1.  Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332).

Authors:  D A Benfield; E Nelson; J E Collins; L Harris; S M Goyal; D Robison; W T Christianson; R B Morrison; D Gorcyca; D Chladek
Journal:  J Vet Diagn Invest       Date:  1992-04       Impact factor: 1.279

2.  A simplified system for generating recombinant adenoviruses.

Authors:  T C He; S Zhou; L T da Costa; J Yu; K W Kinzler; B Vogelstein
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

Review 3.  Vaccinology of classical swine fever: from lab to field.

Authors:  J T van Oirschot
Journal:  Vet Microbiol       Date:  2003-11-07       Impact factor: 3.293

4.  Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination.

Authors:  William A Meier; Judy Galeota; Fernando A Osorio; Robert J Husmann; William M Schnitzlein; Federico A Zuckermann
Journal:  Virology       Date:  2003-04-25       Impact factor: 3.616

5.  The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load.

Authors:  Zhengguo Xiao; Laura Batista; Scott Dee; Patrick Halbur; Michael P Murtaugh
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

6.  Immune response of pigs inoculated with Mycobacterium bovis BCG expressing a truncated form of GP5 and M protein of porcine reproductive and respiratory syndrome virus.

Authors:  Reginaldo G Bastos; Odir A Dellagostin; Raúl G Barletta; Allan R Doster; Eric Nelson; Federico Zuckermann; Fernando A Osorio
Journal:  Vaccine       Date:  2004-01-02       Impact factor: 3.641

7.  Mystery swine disease in The Netherlands: the isolation of Lelystad virus.

Authors:  G Wensvoort; C Terpstra; J M Pol; E A ter Laak; M Bloemraad; E P de Kluyver; C Kragten; L van Buiten; A den Besten; F Wagenaar
Journal:  Vet Q       Date:  1991-07       Impact factor: 3.320

8.  Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group.

Authors:  K K Conzelmann; N Visser; P Van Woensel; H J Thiel
Journal:  Virology       Date:  1993-03       Impact factor: 3.616

9.  Lelystad virus, the causative agent of porcine epidemic abortion and respiratory syndrome (PEARS), is related to LDV and EAV.

Authors:  J J Meulenberg; M M Hulst; E J de Meijer; P L Moonen; A den Besten; E P de Kluyver; G Wensvoort; R J Moormann
Journal:  Virology       Date:  1993-01       Impact factor: 3.616

Review 10.  The challenge of PRRS immunology.

Authors:  E Mateu; I Diaz
Journal:  Vet J       Date:  2007-07-20       Impact factor: 2.688
View more
  5 in total

1.  Targeting Swine Leukocyte Antigen Class I Molecules for Proteasomal Degradation by the nsp1α Replicase Protein of the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Strain JXwn06.

Authors:  Jige Du; Xinna Ge; Ying Liu; Ping Jiang; Zhe Wang; Ruimin Zhang; Lei Zhou; Xin Guo; Jun Han; Hanchun Yang
Journal:  J Virol       Date:  2015-10-21       Impact factor: 5.103

Review 2.  Regulation and evasion of antiviral immune responses by porcine reproductive and respiratory syndrome virus.

Authors:  Chen Huang; Qiong Zhang; Wen-hai Feng
Journal:  Virus Res       Date:  2014-12-18       Impact factor: 3.303

3.  Negative Immunomodulatory Effects of Type 2 Porcine Reproductive and Respiratory Syndrome Virus-Induced Interleukin-1 Receptor Antagonist on Porcine Innate and Adaptive Immune Functions.

Authors:  Teerawut Nedumpun; Navapon Techakriengkrai; Roongroje Thanawongnuwech; Sanipa Suradhat
Journal:  Front Immunol       Date:  2019-03-26       Impact factor: 7.561

Review 4.  Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection.

Authors:  Tong-Qing An; Jiang-Nan Li; Chia-Ming Su; Dongwan Yoo
Journal:  Virus Res       Date:  2020-04-18       Impact factor: 3.303

Review 5.  The Function of the PRRSV-Host Interactions and Their Effects on Viral Replication and Propagation in Antiviral Strategies.

Authors:  Jun Ma; Lulu Ma; Meiting Yang; Wei Wu; Wenhai Feng; Zhongzhou Chen
Journal:  Vaccines (Basel)       Date:  2021-04-09
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.