Literature DB >> 23543851

A Cellular Automata Model of Infection Control on Medical Implants.

Alicia Prieto-Langarica1, Hristo Kojouharov, Benito Chen-Charpentier, Liping Tang.   

Abstract

S. epidermidis infections on medically implanted devices are a common problem in modern medicine due to the abundance of the bacteria. Once inside the body, S. epidermidis gather in communities called biofilms and can become extremely hard to eradicate, causing the patient serious complications. We simulate the complex S. epidermidis-Neutrophils interactions in order to determine the optimum conditions for the immune system to be able to contain the infection and avoid implant rejection. Our cellular automata model can also be used as a tool for determining the optimal amount of antibiotics for combating biofilm formation on medical implants.

Entities:  

Keywords:  Cellular automata; Medical implants; Neutrophils; S. Epidermidis; biofilms

Year:  2011        PMID: 23543851      PMCID: PMC3611882     

Source DB:  PubMed          Journal:  Appl Appl Math        ISSN: 1932-9466


  10 in total

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Authors:  D G Mallet; L G De Pillis
Journal:  J Theor Biol       Date:  2005-09-15       Impact factor: 2.691

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Authors:  Cuong Vuong; Michael Otto
Journal:  Microbes Infect       Date:  2002-04       Impact factor: 2.700

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Authors:  Michael Otto
Journal:  Nat Rev Microbiol       Date:  2009-08       Impact factor: 60.633

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Authors:  Kok-Fai Kong; Cuong Vuong; Michael Otto
Journal:  Int J Med Microbiol       Date:  2006-02-17       Impact factor: 3.473

9.  Phagocytosis of staphylococci biofilms by polymorphonuclear neutrophils: S. aureus and S. epidermidis differ with regard to their susceptibility towards the host defense.

Authors:  Frank Guenther; Petra Stroh; Christoph Wagner; Ursula Obst; Gertrud M Hänsch
Journal:  Int J Artif Organs       Date:  2009-09       Impact factor: 1.595

10.  Fibrin(ogen) mediates acute inflammatory responses to biomaterials.

Authors:  L Tang; J W Eaton
Journal:  J Exp Med       Date:  1993-12-01       Impact factor: 14.307

  10 in total

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