Divya Bajoria1, Thangam Menon. 1. PhD Research Scholar, Department of Microbiology, Dr.A.L.Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras , Taramani, Chennai-600113, India .
Abstract
INTRODUCTION: Rheumatic heart disease (RHD) occurs in 30-45% of the patients with rheumatic fever (RF) and it leads to chronic valvular lesions. The human leukocyte antigen (HLA) might confer a susceptibility to RHD. The aim of the present study was to determine the prevalent HLA class II DR/DQ allelic types which were associated with rheumatic heart disease (RHD) in a small group of south Indian patients and to compare them with those in the control subjects. METHODS: A total of 23 patients who were diagnosed with RHD and 6 control samples were included in this study. A low resolution HLA Class II DR/DQ typing was performed on the blood samples by the PCR-SSP method. RESULTS AND CONCLUSION: The DRB3*01:01:02:01 allele showed a positive association with RHD, whereas the DQB1 loci alleles did not show any significant association.
INTRODUCTION:Rheumatic heart disease (RHD) occurs in 30-45% of the patients with rheumatic fever (RF) and it leads to chronic valvular lesions. The human leukocyte antigen (HLA) might confer a susceptibility to RHD. The aim of the present study was to determine the prevalent HLA class II DR/DQ allelic types which were associated with rheumatic heart disease (RHD) in a small group of south Indian patients and to compare them with those in the control subjects. METHODS: A total of 23 patients who were diagnosed with RHD and 6 control samples were included in this study. A low resolution HLA Class II DR/DQ typing was performed on the blood samples by the PCR-SSP method. RESULTS AND CONCLUSION: The DRB3*01:01:02:01 allele showed a positive association with RHD, whereas the DQB1 loci alleles did not show any significant association.
Entities:
Keywords:
HLA Class II DR/DQ typing; Rheumatic Heart Disease; South India
Authors: K S Reddy; J Narula; R Bhatia; K Shailendri; M Koicha; V Taneja; B Jhingan; R B Pothineni; A N Malaviya; N K Mehra Journal: Indian J Pediatr Date: 1990 Sep-Oct Impact factor: 1.967
Authors: Emmy Okello; Andrea Beaton; Charles K Mondo; Paul Kruszka; Noah Kiwanuka; Richard Odoi-Adome; Juergen Freers Journal: BMC Cardiovasc Disord Date: 2014-02-28 Impact factor: 2.298