OBJECTIVE: Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS: Ga-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, Ga-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion. RESULTS: Ga-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. Ga-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change. CONCLUSION: Ga-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy.
OBJECTIVE:Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-NOTA-RGD PET was used to investigate imaging characteristics in a ratmyocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS:Ga-NOTA-RGD PET was performed serially in rats with MI or sham operation, and myocardial uptake was analyzed with respect to time duration and tissue characteristics. Subsequently, Ga-NOTA-RGD PET was serially performed for therapeutic efficacy monitoring in MI-induced rats, which were treated with basic fibroblast growth factor (bFGF) injection or saline injection. Image findings were compared with the final change in MI lesion. RESULTS:Ga-NOTA-RGD uptake was significantly increased in MI lesion and gradually decreased over time. Ga-NOTA-RGD uptake in the infarcted tissue corresponded with vascular endothelial growth factor expression and macrophage accumulation. In monitoring of therapeutic efficacy, the lesion uptake in the bFGF-injected group was significantly higher than that of the saline-injected and sham-operated groups on the first day. However, no significant differences were observed between bFGF and saline-injected groups at subsequent time points, corresponding to the final infarct size change. CONCLUSION:Ga-NOTA-RGD PET would be a useful angiogenesis imaging modality in MI for assessment of pathophysiology or monitoring of therapeutic efficacy.
Authors: Thomas Ebenhan; Janke Kleynhans; Jan Rijn Zeevaart; Jae Min Jeong; Mike Sathekge Journal: Eur J Nucl Med Mol Imaging Date: 2020-09-12 Impact factor: 9.236
Authors: Thomas Rasmussen; Bjarke Follin; Jens Kastrup; Malene Brandt-Larsen; Jacob Madsen; Thomas Emil Christensen; Karsten Pharao Hammelev; Philip Hasbak; Andreas Kjær Journal: Diagnostics (Basel) Date: 2016-06-17
Authors: Jamila Hedhli; Andrzej Czerwinski; Matthew Schuelke; Agata Płoska; Paweł Sowinski; Lukas La Hood; Spencer B Mamer; John A Cole; Paulina Czaplewska; Maciej Banach; Iwona T Dobrucki; Leszek Kalinowski; Princess Imoukhuede; Lawrence W Dobrucki Journal: Sci Rep Date: 2017-06-09 Impact factor: 4.379
Authors: Geert Hendrikx; Stefan Vöö; Matthias Bauwens; Mark J Post; Felix M Mottaghy Journal: Eur J Nucl Med Mol Imaging Date: 2016-08-12 Impact factor: 9.236