Literature DB >> 23541673

A potential rhodium cancer therapy: studies of a cytotoxic organorhodium(I) complex that binds DNA.

Jeanette R McConnell1, Dimple P Rananaware, Deborah M Ramsey, Kai N Buys, Marcus L Cole, Shelli R McAlpine.   

Abstract

Described is a novel organorhodium(I) complex that is cytotoxic to the colon cancer cell line HCT116 and alters cell migration, DNA replication, and DNA condensation. Most importantly, the mechanism observed is not seen for the parent organorhodium dimer complex [{RhCl(COD)}2], RhCl3, or the free ligand/proligands (COD and 1-(n)butyl-3-methylimidazolium chloride). Thus, the activity of this organorhodium complex is attributable to its unique structure.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23541673      PMCID： PMC3735625          DOI： 10.1016/j.bmcl.2013.03.016

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  27 in total

1.  Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate.

Authors:  Colin G Barry; Elizabeth C Turney; Cynthia S Day; Gilda Saluta; Gregory L Kucera; Ulrich Bierbach
Journal:  Inorg Chem       Date:  2002-12-30       Impact factor: 5.165

2.  Role of DNA-dependent protein kinase in neuronal survival.

Authors:  M Chechlacz; M C Vemuri; J R Naegele
Journal:  J Neurochem       Date:  2001-07       Impact factor: 5.372

3.  Antitumour action of planar, organometallic rhodium(I) complexes.

Authors:  T Giraldi; G Zassinovich; G Mestroni
Journal:  Chem Biol Interact       Date:  1974-12       Impact factor: 5.192

4.  Platinum compounds: a new class of potent antitumour agents.

Authors:  B Rosenberg; L VanCamp; J E Trosko; V H Mansour
Journal:  Nature       Date:  1969-04-26       Impact factor: 49.962

5.  Recognition sequence of specific endonuclease BamH.I from Bacillus amyloliquefaciens H.

Authors:  R J Roberts; G A Wilson; F E Young
Journal:  Nature       Date:  1977-01-06       Impact factor: 49.962

6.  Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1.

Authors:  D J Rossi; A Londesborough; N Korsisaari; A Pihlak; E Lehtonen; M Henkemeyer; T P Mäkelä
Journal:  EMBO J       Date:  2001-06-01       Impact factor: 11.598

Review 7.  Rhodium and its compounds as potential agents in cancer treatment.

Authors:  N Katsaros; A Anagnostopoulou
Journal:  Crit Rev Oncol Hematol       Date:  2002-06       Impact factor: 6.312

8.  Cell-selective biological activity of rhodium metalloinsertors correlates with subcellular localization.

Authors:  Alexis C Komor; Curtis J Schneider; Alyson G Weidmann; Jacqueline K Barton
Journal:  J Am Chem Soc       Date:  2012-11-08       Impact factor: 15.419

9.  Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer.

Authors:  Marcella Lemos Brettas Carneiro; Raphael C A Peixoto; Graziela A Joanitti; Ricardo G S Oliveira; Luis A M Telles; Ana L Miranda-Vilela; Anamélia L Bocca; Leonora M S Vianna; Izabel C R da Silva; Aparecido R de Souza; Zulmira G M Lacava; Sônia N Báo
Journal:  J Nanobiotechnology       Date:  2013-02-16       Impact factor: 10.435

10.  Rapid, simultaneous measurement of DNA, protein, and cell volume in single cells from large mammalian cell populations.

Authors:  H A Crissman; J A Steinkamp
Journal:  J Cell Biol       Date:  1973-12       Impact factor: 10.539
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