Literature DB >> 23541578

3-Bromopyruvate: a novel antifungal agent against the human pathogen Cryptococcus neoformans.

Mariusz Dyląg1, Paweł Lis, Katarzyna Niedźwiecka, Young H Ko, Peter L Pedersen, Andre Goffeau, Stanisław Ułaszewski.   

Abstract

We have investigated the antifungal activity of the pyruvic acid analogue: 3-bromopyruvate (3-BP). Growth inhibition by 3-BP of 110 strains of yeast-like and filamentous fungi was tested by standard spot tests or microdilution method. The human pathogen Cryptococcus neoformans exhibited a low Minimal Inhibitory Concentration (MIC) of 0.12-0.15 mM 3-BP. The high toxicity of 3-BP toward C. neoformans correlated with high intracellular accumulation of 3-BP and also with low levels of intracellular ATP and glutathione. Weak cytotoxicity towards mammalian cells and lack of resistance conferred by the PDR (Pleiotropic Drug Resistance) network in the yeast Saccharomyces cerevisiae, are other properties of 3-BP that makes it a novel promising anticryptococcal drug.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23541578     DOI： 10.1016/j.bbrc.2013.02.125

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  Effect of 3-bromopyruvate and atovaquone on infection during in vitro interaction of Toxoplasma gondii and LLC-MK2 cells.

Authors:  Loyze Paola O de Lima; Sergio H Seabra; Henrique Carneiro; Helene S Barbosa
Journal:  Antimicrob Agents Chemother       Date:  2015-06-15       Impact factor: 5.191

2.  Insights into the carboxyltransferase reaction of pyruvate carboxylase from the structures of bound product and intermediate analogs.

Authors:  Adam D Lietzan; Martin St Maurice
Journal:  Biochem Biophys Res Commun       Date:  2013-10-22       Impact factor: 3.575

Review 3.  The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside.

Authors:  J Azevedo-Silva; O Queirós; F Baltazar; S Ułaszewski; A Goffeau; Y H Ko; P L Pedersen; A Preto; M Casal
Journal:  J Bioenerg Biomembr       Date:  2016-07-25       Impact factor: 2.945

4.  3-bromopyruvate enhanced daunorubicin-induced cytotoxicity involved in monocarboxylate transporter 1 in breast cancer cells.

Authors:  Zhe Liu; Yiming Sun; Haiyu Hong; Surong Zhao; Xue Zou; Renqiang Ma; Chenchen Jiang; Zhiwei Wang; Huabin Li; Hao Liu
Journal:  Am J Cancer Res       Date:  2015-08-15       Impact factor: 6.166

5.  Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans.

Authors:  Qiao-Ling Gu; Yan Zhang; Xi-Mei Fu; Zhao-Lian Lu; Yao Yu; Gen Chen; Rong Ma; Wei Kou; Yong-Mei Lan
Journal:  J Zhejiang Univ Sci B       Date:  2020 Jan.       Impact factor: 3.066

6.  Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate.

Authors:  Paweł Lis; Paweł Jurkiewicz; Magdalena Cal-Bąkowska; Young H Ko; Peter L Pedersen; Andre Goffeau; Stanisław Ułaszewski
Journal:  Oncotarget       Date:  2016-03-01

7.  Glutathione may have implications in the design of 3-bromopyruvate treatment protocols for both fungal and algal infections as well as multiple myeloma.

Authors:  Katarzyna Niedźwiecka; Mariusz Dyląg; Daria Augustyniak; Grażyna Majkowska-Skrobek; Magdalena Cal-Bąkowska; Young H Ko; Peter L Pedersen; Andre Goffeau; Stanisław Ułaszewski
Journal:  Oncotarget       Date:  2016-10-04

Review 8.  Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment.

Authors:  Tengjiao Fan; Guohui Sun; Xiaodong Sun; Lijiao Zhao; Rugang Zhong; Yongzhen Peng
Journal:  Cancers (Basel)       Date:  2019-03-06       Impact factor: 6.639

9.  3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis.

Authors:  Tomasz Jagielski; Katarzyna Niedźwiecka; Katarzyna Roeske; Mariusz Dyląg
Journal:  Front Pharmacol       Date:  2018-04-19       Impact factor: 5.810

10.  The Anticancer Drug 3-Bromopyruvate Induces DNA Damage Potentially Through Reactive Oxygen Species in Yeast and in Human Cancer Cells.

Authors:  Magdalena Cal; Irwin Matyjaszczyk; Ireneusz Litwin; Daria Augustyniak; Rafał Ogórek; Young Ko; Stanisław Ułaszewski
Journal:  Cells       Date:  2020-05-08       Impact factor: 6.600
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.