Literature DB >> 23540984

[Postmenopausal osteoporosis: Primary prevention or excessive use of medications].

C Mendoza-Edroso1, N Sánchez Garrido-Lestache, A Lopez-Picado.   

Abstract

OBJECTIVE: [corrected] Estimate the percentage of excessive use of medicines (bisphosponates, strontium ranelate and raloxifene) in the prevention of fragility fractures in postmenopausal women.
MATERIAL AND METHODS: A descriptive study conducted in an urban health centre in Vitoria-Gasteiz. The participants were women aged between 50 and 70, treated during 2010 with some of aforementioned medicines. Out of the 253 women included, three died, two moved, one did not want to sake part, and another one could not be found, leaving 246 participants. It was determinated if the treatment was or not indicated, as recommended in the ESCEO, NAMS and NOF clinical practice guides. A data search, including fragility fracture history, densitometry performed, densitometry diagnoses, prescribed medicines and prescribing doctor, was carried out by looking in the Osabide and Global Clinic digital clinic records. Interviews were carried out with 72 patients for a more complete information.
RESULTS: The mean patient age was 60.5 ± 4.9 years, and 91,5% of them (225) had undergone a densitometry. Three-quarters (75.1%, 169) had a diagnosis of osteoporosis and 4,4% (11) had previous history of fractures. More than a quarter (27.0%, 68) of treatments had no indication, and varied depending of the prescribing doctor (family doctors: 8.5%/ traumatologists: 58.5%) (p<0.001). The use of the medicine of choice, alendronate in 29.7% of cases, Was significantly higher (59.3%) in Primary Care than in other specialties.
CONCLUSIONS: A high percentage of women are given excessive medication, exposing them to potentially severe secondary damages. Family doctors deal correctly with osteoporosis, with a high percentage of indicated treatments and a rational use of medicines, with alendronate as the first choice in the majority of cases.
Copyright © 2012 Elsevier España, S.L. y SEMERGEN. All rights reserved.

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Year:  2012        PMID: 23540984     DOI: 10.1016/j.semerg.2012.07.006

Source DB:  PubMed          Journal:  Semergen        ISSN: 1138-3593


  1 in total

1.  Enhanced osseointegration of titanium implants in a rat model of osteoporosis using multilayer bone mesenchymal stem cell sheets.

Authors:  Yan Duan; Wei Ma; Dehua Li; Tongfei Wang; Baolin Liu
Journal:  Exp Ther Med       Date:  2017-10-13       Impact factor: 2.447

  1 in total

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