INTRODUCTION:Propofol is a widely used intravenous anesthetic with a number of advantages over intravenous anesthetics used so far.The leading side effect is pain on injection. OBJECTIVE: Aim of the study was to determine the impact of ondansetron, nitrous oxide and alfentanil on reducing pain during propofol application. METHODS: The paper presents a prospective, randomized, single blind study. The study included 120 patients of ASA class I and II, who underwent elective surgery under general anesthesia using propofol for the induction of anesthesia. The patients were divided into four equal groups of 30 patients.The control group received a few milliliters of saline, N group the mixture of nitric oxide and oxygen, O group ondansetron and group A received alfentanil. In all patients, venous occlusion was performed for 60 seconds. Pain assessment was based on the criteria and the score by McCrirrick and Hunter. RESULTS:Pain after the application of propofol was present in 47 (39.2%) patients. The highest frequency of pain was recorded in the control group (18, 60%), and significantly lower (p = 0.009) in the patients who received ondansetron (8; 26.7%) and (p = 0.020), alfentanil (9; 30%).The statistical analysis proved that there was a significant relationship between the groups and the scale of pain (Chi2 = 13.849, p = 0.031). CONCLUSION: Based on the results of our study we can conclude that intravenous ondansetron and alfentanil with venous occlusion can effectively prevent pain during IV use of propofol.
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INTRODUCTION:Propofol is a widely used intravenous anesthetic with a number of advantages over intravenous anesthetics used so far.The leading side effect is pain on injection. OBJECTIVE: Aim of the study was to determine the impact of ondansetron, nitrous oxide and alfentanil on reducing pain during propofol application. METHODS: The paper presents a prospective, randomized, single blind study. The study included 120 patients of ASA class I and II, who underwent elective surgery under general anesthesia using propofol for the induction of anesthesia. The patients were divided into four equal groups of 30 patients.The control group received a few milliliters of saline, N group the mixture of nitric oxide and oxygen, O group ondansetron and group A received alfentanil. In all patients, venous occlusion was performed for 60 seconds. Pain assessment was based on the criteria and the score by McCrirrick and Hunter. RESULTS:Pain after the application of propofol was present in 47 (39.2%) patients. The highest frequency of pain was recorded in the control group (18, 60%), and significantly lower (p = 0.009) in the patients who received ondansetron (8; 26.7%) and (p = 0.020), alfentanil (9; 30%).The statistical analysis proved that there was a significant relationship between the groups and the scale of pain (Chi2 = 13.849, p = 0.031). CONCLUSION: Based on the results of our study we can conclude that intravenous ondansetron and alfentanil with venous occlusion can effectively prevent pain during IV use of propofol.