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Literature DB >> 23539064

Antiestrogen Resistance and the Application of Systems Biology.

Kerrie B Bouker¹, Yue Wang, Jianhua Xuan, Robert Clarke.

Abstract

Understanding the molecular changes that drive an acquired antiestrogen resistance phenotype is of major clinical relevance. Previous methodologies for addressing this question have taken a single gene/pathway approach and the resulting gains have been limited in terms of their clinical impact. Recent systems biology approaches allow for the integration of data from high throughput "-omics" technologies. We highlight recent advances in the field of antiestrogen resistance with a focus on transcriptomics, proteomics and methylomics.

Entities: CellLine Chemical Disease Gene Species

Keywords: Systems biology; antiestrogens; breast cancer; estrogens

Year: 2012 PMID： 23539064 PMCID： PMC3607389 DOI： 10.1016/j.ddmec.2012.10.003

Source DB: PubMed Journal: Drug Discov Today Dis Mech ISSN： 1740-6765

53 in total

1. Autoantibodies to the nuclear phosphoprotein nucleophosmin in breast cancer patients.

Authors: B Brankin; T C Skaar; M Brotzman; B Trock; R Clarke
Journal: Cancer Epidemiol Biomarkers Prev Date: 1998-12 Impact factor: 4.254

Review 2. The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance.

Authors: Cynthie Wong; Shiuan Chen
Journal: J Steroid Biochem Mol Biol Date: 2012-01-08 Impact factor: 4.292

3. Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence.

Authors: Mary Jo Fackler; Christopher B Umbricht; Danielle Williams; Pedram Argani; Leigh-Ann Cruz; Vanessa F Merino; Wei Wen Teo; Zhe Zhang; Peng Huang; Kala Visvananthan; Jeffrey Marks; Stephen Ethier; Joe W Gray; Antonio C Wolff; Leslie M Cope; Saraswati Sukumar
Journal: Cancer Res Date: 2011-08-08 Impact factor: 12.701

Review 4. Molecular and pharmacological aspects of antiestrogen resistance.

Authors: R Clarke; T C Skaar; K B Bouker; N Davis; Y R Lee; J N Welch; F Leonessa
Journal: J Steroid Biochem Mol Biol Date: 2001 Jan-Mar Impact factor: 4.292

Review 5. Histone deacetylase inhibitor induced modulation of anti-estrogen therapy.

Authors: Scott Thomas; Pamela N Munster
Journal: Cancer Lett Date: 2009-01-30 Impact factor: 8.679

6. Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer.

Authors: Robert Clarke; Ayesha N Shajahan; Yue Wang; John J Tyson; Rebecca B Riggins; Louis M Weiner; William T Bauman; Jianhua Xuan; Bai Zhang; Caroline Facey; Harini Aiyer; Katherine Cook; F Edward Hickman; Iman Tavassoly; Anael Verdugo; Chun Chen; Alan Zwart; Anni Wärri; Leena A Hilakivi-Clarke
Journal: Horm Mol Biol Clin Investig Date: 2011-03

7. Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients.

Authors: Nadia Harbeck; Inko Nimmrich; Arndt Hartmann; Jeffrey S Ross; Tanja Cufer; Robert Grützmann; Glen Kristiansen; Angelo Paradiso; Oliver Hartmann; Astrid Margossian; John Martens; Ina Schwope; Antje Lukas; Volkmar Müller; Karin Milde-Langosch; Jörg Nährig; John Foekens; Sabine Maier; Manfred Schmitt; Ralf Lesche
Journal: J Clin Oncol Date: 2008-08-18 Impact factor: 44.544

8. Architecture of the human regulatory network derived from ENCODE data.

Authors: Mark B Gerstein; Anshul Kundaje; Manoj Hariharan; Stephen G Landt; Koon-Kiu Yan; Chao Cheng; Xinmeng Jasmine Mu; Ekta Khurana; Joel Rozowsky; Roger Alexander; Renqiang Min; Pedro Alves; Alexej Abyzov; Nick Addleman; Nitin Bhardwaj; Alan P Boyle; Philip Cayting; Alexandra Charos; David Z Chen; Yong Cheng; Declan Clarke; Catharine Eastman; Ghia Euskirchen; Seth Frietze; Yao Fu; Jason Gertz; Fabian Grubert; Arif Harmanci; Preti Jain; Maya Kasowski; Phil Lacroute; Jing Jane Leng; Jin Lian; Hannah Monahan; Henriette O'Geen; Zhengqing Ouyang; E Christopher Partridge; Dorrelyn Patacsil; Florencia Pauli; Debasish Raha; Lucia Ramirez; Timothy E Reddy; Brian Reed; Minyi Shi; Teri Slifer; Jing Wang; Linfeng Wu; Xinqiong Yang; Kevin Y Yip; Gili Zilberman-Schapira; Serafim Batzoglou; Arend Sidow; Peggy J Farnham; Richard M Myers; Sherman M Weissman; Michael Snyder
Journal: Nature Date: 2012-09-06 Impact factor: 49.962

Antiestrogen Resistance and the Application of Systems Biology.

1. Autoantibodies to the nuclear phosphoprotein nucleophosmin in breast cancer patients.

Review 2. The development, application and limitations of breast cancer cell lines to study tamoxifen and aromatase inhibitor resistance.

3. Genome-wide methylation analysis identifies genes specific to breast cancer hormone receptor status and risk of recurrence.

Review 4. Molecular and pharmacological aspects of antiestrogen resistance.

Review 5. Histone deacetylase inhibitor induced modulation of anti-estrogen therapy.

6. Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer.

7. Multicenter study using paraffin-embedded tumor tissue testing PITX2 DNA methylation as a marker for outcome prediction in tamoxifen-treated, node-negative breast cancer patients.

8. Architecture of the human regulatory network derived from ENCODE data.

9. A co-ordinated interaction between CTCF and ER in breast cancer cells.

10. Identifying cancer biomarkers by network-constrained support vector machines.

1. Preface.

Review 2. Therapeutic Potential for Targeting Autophagy in ER+ Breast Cancer.

Review 3. Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug-Design and Mechanism of Action.