OBJECTIVE: To define the prognostic role of multiple epidemiological, clinical, and biological factors for the development of multiple malignancies (MM) in patients with head and neck cancer (HNC). STUDY DESIGN: Historical cohort study. p53 gene status, microsatellite instability (MSI) of the index tumor, and inherited chromosome fragility (CF) were studied. SETTING: Ninety-six consecutive patients affected by primary HNC, between January 1987 and October 1991, who were eligible for curative radiation therapy were followed up. SUBJECTS AND METHODS: p53 gene status, MSI, and CF in 96 curative radiotherapy-treated patients were correlated with the risk for MM. RESULTS: Multiple malignancies occurred in 28.9%. Microsatellite instability (P = 0.05), CF (P < 0.01), and smoking after treatment of the index tumor (P = 0.02) were correlated with an increased risk of MM. CONCLUSION: Genetic susceptibility may play a central role for MM development in patients with HNC.
OBJECTIVE: To define the prognostic role of multiple epidemiological, clinical, and biological factors for the development of multiple malignancies (MM) in patients with head and neck cancer (HNC). STUDY DESIGN: Historical cohort study. p53 gene status, microsatellite instability (MSI) of the index tumor, and inherited chromosome fragility (CF) were studied. SETTING: Ninety-six consecutive patients affected by primary HNC, between January 1987 and October 1991, who were eligible for curative radiation therapy were followed up. SUBJECTS AND METHODS: p53 gene status, MSI, and CF in 96 curative radiotherapy-treated patients were correlated with the risk for MM. RESULTS:Multiple malignancies occurred in 28.9%. Microsatellite instability (P = 0.05), CF (P < 0.01), and smoking after treatment of the index tumor (P = 0.02) were correlated with an increased risk of MM. CONCLUSION: Genetic susceptibility may play a central role for MM development in patients with HNC.
Entities:
Keywords:
head and neck; inherited chromosome fragility; microsatellite instability; multiple malignancies; p53 gene status
Authors: R Mahieu; G Colletti; P Bonomo; G Parrinello; A Iavarone; G Dolivet; L Livi; A Deganello Journal: Acta Otorhinolaryngol Ital Date: 2016-12 Impact factor: 2.124