Literature DB >> 23535327

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.

Masaki Ohtawa1, Hiroyuki Yamazaki, Daisuke Matsuda, Taichi Ohshiro, Lawrence L Rudel, Satoshi Ōmura, Hiroshi Tomoda, Tohru Nagamitsu.   

Abstract

Synthesis and structure-activity relationships of 7-O-p-cyanobenzoyl pyripyropene A derivatives with modification at C1 and 11 are described. Regioselective mono-deprotection of di-tert-butylsilylene acetal was critical in their synthesis.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23535327     DOI： 10.1016/j.bmcl.2013.02.088

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs.

Authors:  Lian-Sheng Qiao; Xian-Bao Zhang; Lu-di Jiang; Yan-Ling Zhang; Gong-Yu Li
Journal:  Mol Divers       Date:  2016-06-21       Impact factor: 2.943

2.  Phenylpyropenes E and F: new meroterpenes from the marine-derived fungus Penicillium concentricum ZLQ-69.

Authors:  Zhuang Ding; Lianqing Zhang; Juan Fu; Qian Che; Dehai Li; Qianqun Gu; Tianjiao Zhu
Journal:  J Antibiot (Tokyo)       Date:  2015-06-10       Impact factor: 2.649

3.  New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.

Authors:  Taichi Ohshiro; Masaki Ohtawa; Tohru Nagamitsu; Daisuke Matsuda; Hiroaki Yagyu; Matthew A Davis; Lawrence L Rudel; Shun Ishibashi; Hiroshi Tomoda
Journal:  J Pharmacol Exp Ther       Date:  2015-09-03       Impact factor: 4.030

4.  In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.

Authors:  Daisuke Matsuda; Taichi Ohshiro; Masaki Ohtawa; Hiroyuki Yamazaki; Tohru Nagamitsu; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2014-07-09       Impact factor: 2.649

5.  Characterization of two acetyltransferase genes in the pyripyropene biosynthetic gene cluster from Penicillium coprobium.

Authors:  Jie Hu; Ayako Furutani; Kentaro Yamamoto; Kazuhiko Oyama; Masaaki Mitomi; Hiroyuki Anzai
Journal:  Biotechnol Biotechnol Equip       Date:  2014-10-31       Impact factor: 1.632

Review 6.  Exploration of marine natural resources in Indonesia and development of efficient strategies for the production of microbial halogenated metabolites.

Authors:  Hiroyuki Yamazaki
Journal:  J Nat Med       Date:  2021-08-20       Impact factor: 2.343
  6 in total

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