Literature DB >> 23533266

Safe drug use in long QT syndrome and Brugada syndrome: comparison of website statistics.

Pieter G Postema1, Jon Neville, Jonas S S G de Jong, Klaus Romero, Arthur A M Wilde, Raymond L Woosley.   

Abstract

AIMS: We sought to obtain insights into the efficacy of two websites, www.QTdrugs.org and www.BrugadaDrugs.org, that have the intention to prevent fatal arrhythmias due to unsafe drug use in Long QT syndrome and Brugada syndrome. METHODS AND
RESULTS: Prospective web-use statistical analysis combined with online surveys were employed. Our main outcome measure was the percentage of Long QT syndrome patients and Brugada syndrome patients reporting refraining or discontinuation of possible unsafe drugs. QTdrugs.org has received >3 100 000 visitors from 180 countries. Most visitors originated from the Americas (87%), as compared with Europe (7%), Asia (3%), Oceania (2%), and Africa (1%). The QTdrugs.org survey yielded 340 respondents: 34% were patients and 50% medical professionals. Of the patients, 79% reported that they refrained from, and 61% reported discontinuing drugs due to the website. The website was very much appreciated by 65% of the respondents and 30% found it rather helpful. The BrugadaDrugs.org received >48 000 visitors from 154 countries. Most visitors originated from Europe (46%) and the Americas (39%), but less from Asia (10%), Oceania (4%), and Africa (<1%). The BrugadaDrugs.org survey yielded 178 respondents: 68% were patients and 21% medical professionals. Of the patients, 72% reported refraining from, and 48% discontinuing drugs due to the website. The website was very much appreciated by 72% of the respondents and 25% found it rather helpful.
CONCLUSION: These websites are extensively used, they promote drug awareness, and they help patients to avoid possible pro-arrhythmic drugs. Visitors find the websites valuable but should note their limitations.

Entities:  

Keywords:  Brugada syndrome; Cardiac arrest; Drugs; Long QT syndrome; Side effects; website statistics; website use

Mesh:

Year:  2013        PMID: 23533266      PMCID: PMC3857912          DOI: 10.1093/europace/eut018

Source DB:  PubMed          Journal:  Europace        ISSN: 1099-5129            Impact factor:   5.214


  27 in total

1.  Prevalence of the congenital long-QT syndrome.

Authors:  Peter J Schwartz; Marco Stramba-Badiale; Lia Crotti; Matteo Pedrazzini; Alessandra Besana; Giuliano Bosi; Fulvio Gabbarini; Karine Goulene; Roberto Insolia; Savina Mannarino; Fabio Mosca; Luigi Nespoli; Alessandro Rimini; Enrico Rosati; Patrizia Salice; Carla Spazzolini
Journal:  Circulation       Date:  2009-10-19       Impact factor: 29.690

Review 2.  Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death.

Authors:  Iris C R M Kolder; Michael W T Tanck; Connie R Bezzina
Journal:  J Mol Cell Cardiol       Date:  2012-01-08       Impact factor: 5.000

3.  Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management.

Authors:  Ilan Goldenberg; James Bradley; Arthur Moss; Scott McNitt; Slava Polonsky; Jennifer L Robinson; Mark Andrews; Wojciech Zareba
Journal:  J Cardiovasc Electrophysiol       Date:  2010-03-05

4.  A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.

Authors:  Carmen R Valdivia; Michael J Ackerman; David J Tester; Tomoyuki Wada; Jorge McCormack; Bin Ye; Jonathan C Makielski
Journal:  Cardiovasc Res       Date:  2002-08-01       Impact factor: 10.787

5.  Excellent long-term reproducibility of the electrophysiologic efficacy of quinidine in patients with idiopathic ventricular fibrillation and Brugada syndrome.

Authors:  Bernard Belhassen; Aharon Glick; Sami Viskin
Journal:  Pacing Clin Electrophysiol       Date:  2009-03       Impact factor: 1.976

6.  Monitoring the safety of antiepileptic medication in a child with Brugada syndrome.

Authors:  V Van Gorp; D Danschutter; L Huyghens; S Hachimi-Idrissi; A Sarkozy; G B Chierchia; S Henkens; P Brugada
Journal:  Int J Cardiol       Date:  2009-02-07       Impact factor: 4.164

7.  Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease.

Authors:  Edward Sze; Arthur J Moss; Ilan Goldenberg; Scott McNitt; Christian Jons; Wojciech Zareba; Ming Qi; Jennifer L Robinson
Journal:  Ann Noninvasive Electrocardiol       Date:  2008-10       Impact factor: 1.468

8.  High efficacy of beta-blockers in long-QT syndrome type 1: contribution of noncompliance and QT-prolonging drugs to the occurrence of beta-blocker treatment "failures".

Authors:  G Michael Vincent; Peter J Schwartz; Isabelle Denjoy; Heikki Swan; Candice Bithell; Carla Spazzolini; Lia Crotti; Kirsi Piippo; Jean-Marc Lupoglazoff; Elizabeth Villain; Silvia G Priori; Carlo Napolitano; Li Zhang
Journal:  Circulation       Date:  2008-12-31       Impact factor: 29.690

9.  Empiric quinidine therapy for asymptomatic Brugada syndrome: time for a prospective registry.

Authors:  Sami Viskin; Arthur A M Wilde; Hanno L Tan; Charles Antzelevitch; Wataru Shimizu; Bernard Belhassen
Journal:  Heart Rhythm       Date:  2008-12-03       Impact factor: 6.343

10.  Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES).

Authors:  Gunther Eysenbach
Journal:  J Med Internet Res       Date:  2004-09-29       Impact factor: 5.428

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  16 in total

Review 1.  Update on Cardiovascular Safety of Tyrosine Kinase Inhibitors: With a Special Focus on QT Interval, Left Ventricular Dysfunction and Overall Risk/Benefit.

Authors:  Rashmi R Shah; Joel Morganroth
Journal:  Drug Saf       Date:  2015-08       Impact factor: 5.606

Review 2.  Anaesthesia for patients with hereditary arrhythmias part I: Brugada syndrome.

Authors:  D Levy; C Bigham; D Tomlinson
Journal:  BJA Educ       Date:  2018-03-28

3.  Sugammadex in a Patient with Brugada Syndrome.

Authors:  Ebru Biricik; Zehra Hatipoğlu; Çağatay Küçükbingöz
Journal:  Turk J Anaesthesiol Reanim       Date:  2016-04-01

Review 4.  Channelopathies - emerging trends in the management of inherited arrhythmias.

Authors:  Priya Chockalingam; Yuka Mizusawa; Arthur Am Wilde
Journal:  Indian Pacing Electrophysiol J       Date:  2015-04-01

Review 5.  Brugada syndrome and its relevance in the perioperative period.

Authors:  Dan Sorajja; Harish Ramakrishna; A Karl Poterack; Win-Kuang Shen; Farouk Mookadam
Journal:  Ann Card Anaesth       Date:  2015 Jul-Sep

Review 6.  Disease Modifiers of Inherited SCN5A Channelopathy.

Authors:  Arie O Verkerk; Ahmad S Amin; Carol Ann Remme
Journal:  Front Cardiovasc Med       Date:  2018-10-01

7.  Ageing and Brugada syndrome: considerations and recommendations.

Authors:  Pieter G Postema; Hanno L Tan; Arthur Am Wilde
Journal:  J Geriatr Cardiol       Date:  2013-03       Impact factor: 3.327

8.  Pilot Study of Return of Genetic Results to Patients in Adult Nephrology.

Authors:  Jordan G Nestor; Maddalena Marasa; Hila Milo-Rasouly; Emily E Groopman; S Ali Husain; Sumit Mohan; Hilda Fernandez; Vimla S Aggarwal; Dina F Ahram; Natalie Vena; Kelsie Bogyo; Andrew S Bomback; Jai Radhakrishnan; Gerald B Appel; Wooin Ahn; David J Cohen; Pietro A Canetta; Geoffrey K Dube; Maya K Rao; Heather K Morris; Russell J Crew; Simone Sanna-Cherchi; Krzysztof Kiryluk; Ali G Gharavi
Journal:  Clin J Am Soc Nephrol       Date:  2020-04-16       Impact factor: 10.614

9.  Increasing gap junction coupling suppresses ibutilide-induced torsades de pointes.

Authors:  Lei Ruan; Xiaoqing Quan; Liandong Li; Rong Bai; Mingke Ni; Rende Xu; Cuntai Zhang
Journal:  Exp Ther Med       Date:  2014-03-04       Impact factor: 2.447

Review 10.  The measurement of the QT interval.

Authors:  Pieter G Postema; Arthur A M Wilde
Journal:  Curr Cardiol Rev       Date:  2014-08
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