CONTEXT: Low serum calcidiol has been associated with multiple comorbidities and mortality but no "safe" range has been found for the upper concentration. OBJECTIVE: We aim to establish the upper threshold of serum calcidiol, beyond which there is an increased risk for acute coronary syndrome and/or mortality. DESIGN, SETTING, AND PARTICIPANTS: We extracted data for 1,282,822 Clalit Health Services members aged >45 between July 2007 and December 2011. Records of mortality or acute coronary syndrome were extracted during the follow-up period. Kaplan-Meier analysis calculated time to episode and Cox regression models generated adjusted hazard ratios for episode by calcidiol group (<10, 10.1-20, 20.1-36, and >36.1 ng/mL). OUTCOME MEASURES: Acute coronary syndrome subsuming all-cause mortality. RESULTS: During the 54-month study period, 422,822 Clalit Health Services members were tested for calcidiol, of which 12,280 died of any cause (905 with acute coronary syndrome) and 3933 were diagnosed with acute coronary syndrome. Compared to those with 20-36 ng/mL, the adjusted hazard ratios among those with levels of <10, 10-20, and >36 ng/mL were 1.88 (confidence interval [CI]: 1.80-1.96), 1.25 (CI: 1.21-1.30), and 1.13 (CI: 1.04-1.22) (P < .05), respectively. LIMITATIONS: The study cohort comprised only 30% of the population, those tested for vitamin D. The small sample size of those with calcidiol >36 ng/mL prevented further analysis of this group. CONCLUSIONS: Vitamin D in the 20-36 ng/mL range was associated with the lowest risk for mortality and morbidity. The hazard ratio below and above this range increases significantly.
CONTEXT: Low serum calcidiol has been associated with multiple comorbidities and mortality but no "safe" range has been found for the upper concentration. OBJECTIVE: We aim to establish the upper threshold of serum calcidiol, beyond which there is an increased risk for acute coronary syndrome and/or mortality. DESIGN, SETTING, AND PARTICIPANTS: We extracted data for 1,282,822 Clalit Health Services members aged >45 between July 2007 and December 2011. Records of mortality or acute coronary syndrome were extracted during the follow-up period. Kaplan-Meier analysis calculated time to episode and Cox regression models generated adjusted hazard ratios for episode by calcidiol group (<10, 10.1-20, 20.1-36, and >36.1 ng/mL). OUTCOME MEASURES: Acute coronary syndrome subsuming all-cause mortality. RESULTS: During the 54-month study period, 422,822 Clalit Health Services members were tested for calcidiol, of which 12,280 died of any cause (905 with acute coronary syndrome) and 3933 were diagnosed with acute coronary syndrome. Compared to those with 20-36 ng/mL, the adjusted hazard ratios among those with levels of <10, 10-20, and >36 ng/mL were 1.88 (confidence interval [CI]: 1.80-1.96), 1.25 (CI: 1.21-1.30), and 1.13 (CI: 1.04-1.22) (P < .05), respectively. LIMITATIONS: The study cohort comprised only 30% of the population, those tested for vitamin D. The small sample size of those with calcidiol >36 ng/mL prevented further analysis of this group. CONCLUSIONS:Vitamin D in the 20-36 ng/mL range was associated with the lowest risk for mortality and morbidity. The hazard ratio below and above this range increases significantly.
Authors: Christopher R Sudfeld; Christopher Duggan; Said Aboud; Roland Kupka; Karim P Manji; Rodrick Kisenge; Wafaie W Fawzi Journal: J Nutr Date: 2014-11-12 Impact factor: 4.798
Authors: Simon Hsu; David K Prince; Kayleen Williams; Norrina B Allen; Gregory L Burke; Andrew N Hoofnagle; Xiaohui Li; Kiang J Liu; Robyn L McClelland; Erin D Michos; Bruce M Psaty; Steven J Shea; Kenneth M Rice; Jerome I Rotter; David Siscovick; Russell P Tracy; Karol E Watson; Bryan R Kestenbaum; Ian H de Boer Journal: Am J Clin Nutr Date: 2022-03-04 Impact factor: 7.045
Authors: A Granic; T R Hill; T B L Kirkwood; K Davies; J Collerton; C Martin-Ruiz; T von Zglinicki; B K Saxby; K A Wesnes; D Collerton; J C Mathers; C Jagger Journal: Eur J Neurol Date: 2014-08-13 Impact factor: 6.089
Authors: A Granic; T Aspray; T Hill; K Davies; J Collerton; C Martin-Ruiz; T von Zglinicki; T B L Kirkwood; J C Mathers; C Jagger Journal: J Intern Med Date: 2014-06-20 Impact factor: 8.989
Authors: Rajiv Chowdhury; Setor Kunutsor; Anna Vitezova; Clare Oliver-Williams; Susmita Chowdhury; Jessica C Kiefte-de-Jong; Hassan Khan; Cristina P Baena; Dorairaj Prabhakaran; Moshe B Hoshen; Becca S Feldman; An Pan; Laura Johnson; Francesca Crowe; Frank B Hu; Oscar H Franco Journal: BMJ Date: 2014-04-01