Literature DB >> 23529905

Mimicking nanofibrous hybrid bone substitute for mesenchymal stem cells differentiation into osteogenesis.

Chinnasamy Gandhimathi1, Jayarama Venugopal, Rajeswari Ravichandran, Subramanian Sundarrajan, Shanmugavel Suganya, Seeram Ramakrishna.   

Abstract

Mimicking hybrid extracellular matrix is one of the main challenges for bone tissue engineering (BTE). Biocompatible polycaprolactone/poly(α,β)-DL-aspartic acid/collagen nanofibrous scaffolds were fabricated by electrospinning and nanohydroxyapatite (n-HA) was deposited by calcium phosphate dipping method for BTE. Human mesenchymal stem cells (hMSCs) were cultured on these hybrid scaffolds to investigate the cell proliferation, osteogenic differentiation by alkaline phosphatase activity, mineralization, double immunofluorescent staining using CD90 and expression of osteocalcin. The present study indicated that the PCL/PAA/collagen/n-HA scaffolds promoted greater osteogenic differentiation of hMSCs, proving to be a potential hybrid scaffolds for BTE.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2013        PMID： 23529905     DOI： 10.1002/mabi.201200435

Source DB:  PubMed          Journal:  Macromol Biosci        ISSN： 1616-5187            Impact factor:   4.979


  10 in total

1.  Nanotopographical Surfaces for Stem Cell Fate Control: Engineering Mechanobiology from the Bottom.

Authors:  Weiqiang Chen; Yue Shao; Xiang Li; Gang Zhao; Jianping Fu
Journal:  Nano Today       Date:  2014-12-01       Impact factor: 20.722

2.  Nanofibrous spongy microspheres to deliver rabbit mesenchymal stem cells and anti-miR-199a to regenerate nucleus pulposus and prevent calcification.

Authors:  Ganjun Feng; Zhanpeng Zhang; Ming Dang; Kunal J Rambhia; Peter X Ma
Journal:  Biomaterials       Date:  2020-06-21       Impact factor: 12.479

3.  Biocomposite nanofibrous strategies for the controlled release of biomolecules for skin tissue regeneration.

Authors:  Chinnasamy Gandhimathi; Jayarama Reddy Venugopal; Velmurugan Bhaarathy; Seeram Ramakrishna; Srinivasan Dinesh Kumar
Journal:  Int J Nanomedicine       Date:  2014-10-08

Review 4.  Nanotechnology in the regulation of stem cell behavior.

Authors:  King-Chuen Wu; Ching-Li Tseng; Chi-Chang Wu; Feng-Chen Kao; Yuan-Kun Tu; Edmund C So; Yang-Kao Wang
Journal:  Sci Technol Adv Mater       Date:  2013-10-11       Impact factor: 8.090

Review 5.  Emerging Perspectives in Scaffold for Tissue Engineering in Oral Surgery.

Authors:  Gabriele Ceccarelli; Rossella Presta; Laura Benedetti; Maria Gabriella Cusella De Angelis; Saturnino Marco Lupi; Ruggero Rodriguez Y Baena
Journal:  Stem Cells Int       Date:  2017-02-26       Impact factor: 5.443

6.  Poly(aspartic acid) Biohydrogel as the Base of a New Hybrid Conducting Material.

Authors:  Adrián Fontana-Escartín; Guillem Ruano; Fiorella M Silva; Francesc Estrany; Jordi Puiggalí; Carlos Alemán; Juan Torras
Journal:  Int J Mol Sci       Date:  2021-12-06       Impact factor: 5.923

7.  An electrospun poly(ε-caprolactone) nanocomposite fibrous mat with a high content of hydroxyapatite to promote cell infiltration.

Authors:  Haoxuan Li; Chen Huang; Xiangyu Jin; Qinfei Ke
Journal:  RSC Adv       Date:  2018-07-16       Impact factor: 3.361

8.  Effects of nanofiber scaffolds coated with nanoparticulate and micro-particulate FDBA on the morphology, adhesion and proliferation of human mesenchymal stem cells.

Authors:  Shabnam Aghayan; Ehsan Seyedjafari; Shadi Hamidi
Journal:  Iran Biomed J       Date:  2022-05-01

9.  A radiopaque electrospun scaffold for engineering fibrous musculoskeletal tissues: Scaffold characterization and in vivo applications.

Authors:  John T Martin; Andrew H Milby; Kensuke Ikuta; Subash Poudel; Christian G Pfeifer; Dawn M Elliott; Harvey E Smith; Robert L Mauck
Journal:  Acta Biomater       Date:  2015-08-03       Impact factor: 8.947

10.  Osteogenic Differentiation of Mesenchymal Stem Cells with Silica-Coated Gold Nanoparticles for Bone Tissue Engineering.

Authors:  Chinnasamy Gandhimathi; Ying Jie Quek; Hariharan Ezhilarasu; Seeram Ramakrishna; Boon-Huat Bay; Dinesh Kumar Srinivasan
Journal:  Int J Mol Sci       Date:  2019-10-16       Impact factor: 5.923
  10 in total

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