PURPOSE: Liposarcoma represents the most common soft tissue tumors in adults. The tumors are characterized by a high morphological diversity and a great variation in biological behavior. Atypical lipomatous tumors represent a distinctive subset of mesenchymal neoplasms featuring mature adipocytic differentiation. Histologically, atypical lipomatous tumor might be easily confused with lipoma. Conversely, dedifferentiated liposarcoma may be confused with other spindle cell/pleomorphic undifferentiated tumors. METHODS: A group of liposarcomas was analyzed by investigating the MDM2, CDK4, and HMGI-C proteins. The study was extended to a group of lipomas and non-lipomatous sarcomas, to determine whether the immunohistochemical investigation of these proteins might play any diagnostic role. RESULTS: Our data suggest that ordinary lipomas may form a molecular genetic and morphological continuum with atypical lipomatous tumor. At one end of the spectrum are lipomas characterized by HMGI-C activation and at the other end are atypical lipomatous tumors with overrepresentation of the HMGI-C, CDK4, or MDM2 proteins. These findings not only provide insights into the molecular pathogenesis of lipomatous tumors, but also indicate that the immunohistochemical analysis of HMGI-C, CDK4, or MDM2 may help to increase diagnostic accuracy. CONCLUSIONS: HMGI-C is a useful adjunct in the diagnosis of atypical lipomatous tumor and dedifferentiated liposarcoma and differentiates them from their mimics. Therefore, in our experience, HMGI-C expression alone is of rather limited value in the differential diagnosis of liposarcoma subtypes.
PURPOSE:Liposarcoma represents the most common soft tissue tumors in adults. The tumors are characterized by a high morphological diversity and a great variation in biological behavior. Atypical lipomatous tumors represent a distinctive subset of mesenchymal neoplasms featuring mature adipocytic differentiation. Histologically, atypical lipomatous tumor might be easily confused with lipoma. Conversely, dedifferentiated liposarcoma may be confused with other spindle cell/pleomorphic undifferentiated tumors. METHODS: A group of liposarcomas was analyzed by investigating the MDM2, CDK4, and HMGI-C proteins. The study was extended to a group of lipomas and non-lipomatous sarcomas, to determine whether the immunohistochemical investigation of these proteins might play any diagnostic role. RESULTS: Our data suggest that ordinary lipomas may form a molecular genetic and morphological continuum with atypical lipomatous tumor. At one end of the spectrum are lipomas characterized by HMGI-C activation and at the other end are atypical lipomatous tumors with overrepresentation of the HMGI-C, CDK4, or MDM2 proteins. These findings not only provide insights into the molecular pathogenesis of lipomatous tumors, but also indicate that the immunohistochemical analysis of HMGI-C, CDK4, or MDM2 may help to increase diagnostic accuracy. CONCLUSIONS:HMGI-C is a useful adjunct in the diagnosis of atypical lipomatous tumor and dedifferentiated liposarcoma and differentiates them from their mimics. Therefore, in our experience, HMGI-C expression alone is of rather limited value in the differential diagnosis of liposarcoma subtypes.
Authors: A P Dei Tos; C Doglioni; S Piccinin; R Sciot; A Furlanetto; M Boiocchi; P Dal Cin; R Maestro; C D Fletcher; G Tallini Journal: J Pathol Date: 2000-04 Impact factor: 7.996
Authors: Ronald S A de Vreeze; Daphne de Jong; Ivon H G Tielen; Henrique J Ruijter; Petra M Nederlof; Rick L Haas; Frits van Coevorden Journal: Mod Pathol Date: 2008-09-26 Impact factor: 7.842
Authors: Joshua Weaver; John R Goldblum; Sondra Turner; Raymond R Tubbs; Wei-Lein Wang; Alexander Jf Lazar; Brian P Rubin Journal: Mod Pathol Date: 2008-10-03 Impact factor: 7.842
Authors: Rosalvo Zósimo Bispo Júnior; Olavo Pires de Camargo; Cláudia Regina G C M de Oliveira; Renée Zon Filippi; André Mathias Baptista; Marcelo Tadeu Caiero Journal: Clinics (Sao Paulo) Date: 2008-04 Impact factor: 2.365