Literature DB >> 2352925

Introduction of the beta isozyme of protein kinase C accelerates induced differentiation of murine erythroleukemia cells.

E Melloni1, S Pontremoli, B Sparatore, M Patrone, F Grossi, P A Marks, R A Rifkind.   

Abstract

Induction of differentiation in murine erythroleukemia cells (MELCs) involves a protein kinase C (PKC)-mediated step. Vincristine-resistant cells respond more rapidly to hybrid polar/apolar inducers than the parental cells. These vincristine-resistant MELCs contain elevated levels of the beta isozyme of PKC (PKC-beta). Exogenous homologous murine PKC-beta, incorporated into permeabilized MELCs, accelerates induced differentiation. Neither rat PKC-beta, nor mouse PKC-alpha, nor rat PKC-alpha, incorporated into permeabilized MELCs, is effective in altering the kinetics of induced differentiation. This provides direct evidence for a rate-limiting role for this PKC isozyme during N,N'-hexamethylenebisacetamide-mediated induced differentiation of a transformed cell.

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Year:  1990        PMID： 2352925      PMCID： PMC54125          DOI： 10.1073/pnas.87.12.4417

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  Induction by ouabain of hemoglobin synthesis in cultured Friend erythroleukemic cells.

Authors:  A Bernstein; D M Hunt; V Crichley; T W Mak
Journal:  Cell       Date:  1976-11       Impact factor: 41.582

2.  Changes in cyclic adenosine 3':5'-monophosphate levels during induction of differentiation in murine erythroleukemia cells.

Authors:  Y Gazitt; R C Reuben; A D Deitch; P A Marks; R A Rifkind
Journal:  Cancer Res       Date:  1978-11       Impact factor: 12.701

3.  The program of Friend cell erythroid differentiation: early changes in Na+/K+ ATPase function.

Authors:  D Mager; A Bernstein
Journal:  J Supramol Struct       Date:  1978

4.  Effect of hexamethylene bisacetamide on the commitment to differentiation of murine erythroleukemia cells.

Authors:  E Fibach; R C Reuben; R A Rifkind; P A Marks
Journal:  Cancer Res       Date:  1977-02       Impact factor: 12.701

5.  Cell volume changes in relation to the cell cycle of differentiating erythroleukemic cells.

Authors:  Y Gazitt; A D Deitch; P A Marks; R A Rifkind
Journal:  Exp Cell Res       Date:  1978-12       Impact factor: 3.905

6.  Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation.

Authors:  E Melloni; S Pontremoli; P L Viotti; M Patrone; P A Marks; R A Rifkind
Journal:  J Biol Chem       Date:  1989-11-05       Impact factor: 5.157

7.  Expression of c-myc changes during differentiation of mouse erythroleukaemia cells.

Authors:  H M Lachman; A I Skoultchi
Journal:  Nature       Date:  1984 Aug 16-22       Impact factor: 49.962

8.  Inducer-mediated commitment of murine erythroleukemia cells to differentiation: a multistep process.

Authors:  Z Chen; J Banks; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

9.  A new group of potent inducers of differentiation in murine erythroleukemia cells.

Authors:  R C Reuben; R L Wife; R Breslow; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

10.  Calcium regulates the commitment of murine erythroleukemia cells to terminal erythroid differentiation.

Authors:  K Bridges; R Levenson; D Housman; L Cantley
Journal:  J Cell Biol       Date:  1981-08       Impact factor: 10.539
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  7 in total

1.  Dexniguldipine hydrochloride, a protein-kinase-C-specific inhibitor, affects the cell cycle, differentiation, P-glycoprotein levels, and nuclear protein phosphorylation in Friend erythroleukemia cells.

Authors:  K K Patterson; B S Beckman; D M Klotz; C M Mallia; J R Jeter
Journal:  J Cancer Res Clin Oncol       Date:  1996       Impact factor: 4.553

2.  Protein kinase C isozymes epsilon and alpha in murine erythroleukemia cells.

Authors:  C T Powell; L Leng; L Dong; H Kiyokawa; X Busquets; K O'Driscoll; P A Marks; R A Rifkind
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

3.  Characteristics of erythroleukemia cells selected for vincristine resistance that have accelerated inducer-mediated differentiation.

Authors:  V M Richon; N Weich; L Leng; H Kiyokawa; L Ngo; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-01       Impact factor: 11.205

4.  G-protein-coupled receptors in normal human erythroid progenitor cells.

Authors:  H Porzig; R Gutknecht; G Kostova; K Thalmeier
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

5.  Involvement of protein kinase C in growth regulation of human meningioma cells.

Authors:  T Todo; R Fahlbusch
Journal:  Acta Neurochir (Wien)       Date:  1994       Impact factor: 2.216

6.  Antisense oligodeoxynucleotide inhibition of delta protein kinase C expression accelerates induced differentiation of murine erythroleukaemia cells.

Authors:  A Pessino; M Passalacqua; B Sparatore; M Patrone; E Melloni; S Pontremoli
Journal:  Biochem J       Date:  1995-12-01       Impact factor: 3.857

7.  Changes in calcium influx affect the differentiation of murine erythroleukaemia cells.

Authors:  B Sparatore; A Pessino; M Patrone; M Passalacqua; E Melloni; S Pontremoli
Journal:  Biochem J       Date:  1995-01-01       Impact factor: 3.857
  7 in total

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