Literature DB >> 23528300

Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.

Arun P Chandrasekharappa1, Sangamesh E Badiger, Pramod K Dubey, Sunil K Panigrahi, Sekhar Reddy V V V Manukonda.   

Abstract

A series of benzoxazole compounds containing oxamic acid were synthesized and screened for the PTP1B inhibition. Compound 31d showed best biochemical potency (Ki) of 6.7 μM. Structure-activity relationship were explained with the help of molecular modeling approach.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23528300     DOI： 10.1016/j.bmcl.2013.02.109

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century.

Authors:  Mara Ibeth Campos-Almazán; Alicia Hernández-Campos; Rafael Castillo; Erick Sierra-Campos; Mónica Valdez-Solana; Claudia Avitia-Domínguez; Alfredo Téllez-Valencia
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-14

2.  Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping.

Authors:  András Váradi; Travis C Palmer; Paula R Notis; Gabriel N Redel-Traub; Daniel Afonin; Joan J Subrath; Gavril W Pasternak; Chunhua Hu; Indrajeet Sharma; Susruta Majumdar
Journal:  Org Lett       Date:  2014-02-28       Impact factor: 6.005

Review 3.  Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles.

Authors:  András Váradi; Travis C Palmer; Rebecca Notis Dardashti; Susruta Majumdar
Journal:  Molecules       Date:  2015-12-23       Impact factor: 4.411
  3 in total

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