| Literature DB >> 23528142 |
Akira Mizuno1, Shiho Miura, Mizuki Watanabe, Yoshihiko Ito, Shizuo Yamada, Takenao Odagami, Yuji Kogami, Mitsuhiro Arisawa, Satoshi Shuto.
Abstract
Conformationally restricted peptidomimetics comprising eight stereoisomeric scaffolds with three-dimensional structural diversity were designed based on the structural features of cyclopropane, that is, cyclopropylic strain, which mimic wide-ranging tetrapeptide conformations covering β-turns through β-strands. Stereoselective synthesis of the designed peptidomimetics led to the identification of nonpeptidic melanocortin-4 receptor ligands.Entities:
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Year: 2013 PMID： 23528142 DOI： 10.1021/ol400469w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005