BACKGROUND: Bronchial asthma is a chronic inflammatory condition associated with increased cardiovascular (CV) events. Here, we assess arterial inflammation, using 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging (FDG-PET/CT), in patients with bronchial asthma and low to intermediate Framingham risk scores (FRS). METHODS: A total of 102 patients underwent FDG-PET/CT imaging for clinical indications. Thirty-four patients (mean age 54.9 ± 16.1) with mild asthma and no known atherosclerotic disease were compared to 2 non-asthmatic groups. The first control group (n = 34) were matched by age, gender, and FRS. The second control group (n = 34) had clinical atherosclerosis and were matched by gender. Thereafter, arterial FDG uptake on PET images was determined, while blinded to patient identifiers. RESULTS: Target-to-background-ratio (TBR) in the aorta was higher in asthmatics vs non-asthmatic FRS-matched controls (1.96 ± 0.26 vs 1.76 ± 0.20; P < .001). The aortic TBR remained elevated in asthmatics vs non-asthmatic controls after adjusting traditional CV risk factors (P < .001). An inverse correlation was observed between FDG uptake and lung function, FEV1 (P = .02) and peak flow (P = .03). CONCLUSIONS: Bronchial asthma is associated with increased arterial inflammation beyond that estimated by current risk stratification tools. Further studies are required to evaluate whether attenuation of systemic inflammation will decrease CV events.
BACKGROUND:Bronchial asthma is a chronic inflammatory condition associated with increased cardiovascular (CV) events. Here, we assess arterial inflammation, using 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging (FDG-PET/CT), in patients with bronchial asthma and low to intermediate Framingham risk scores (FRS). METHODS: A total of 102 patients underwent FDG-PET/CT imaging for clinical indications. Thirty-four patients (mean age 54.9 ± 16.1) with mild asthma and no known atherosclerotic disease were compared to 2 non-asthmatic groups. The first control group (n = 34) were matched by age, gender, and FRS. The second control group (n = 34) had clinical atherosclerosis and were matched by gender. Thereafter, arterial FDG uptake on PET images was determined, while blinded to patient identifiers. RESULTS: Target-to-background-ratio (TBR) in the aorta was higher in asthmatics vs non-asthmatic FRS-matched controls (1.96 ± 0.26 vs 1.76 ± 0.20; P < .001). The aortic TBR remained elevated in asthmatics vs non-asthmatic controls after adjusting traditional CV risk factors (P < .001). An inverse correlation was observed between FDG uptake and lung function, FEV1 (P = .02) and peak flow (P = .03). CONCLUSIONS:Bronchial asthma is associated with increased arterial inflammation beyond that estimated by current risk stratification tools. Further studies are required to evaluate whether attenuation of systemic inflammation will decrease CV events.
Authors: K H In; K Asano; D Beier; J Grobholz; P W Finn; E K Silverman; E S Silverman; T Collins; A R Fischer; T P Keith; K Serino; S W Kim; G T De Sanctis; C Yandava; A Pillari; P Rubin; J Kemp; E Israel; W Busse; D Ledford; J J Murray; A Segal; D Tinkleman; J M Drazen Journal: J Clin Invest Date: 1997-03-01 Impact factor: 14.808
Authors: James H F Rudd; Kelly S Myers; Sameer Bansilal; Josef Machac; Ash Rafique; Michael Farkouh; Valentin Fuster; Zahi A Fayad Journal: J Am Coll Cardiol Date: 2007-08-13 Impact factor: 24.094
Authors: Axel Rominger; Tobias Saam; Sarah Wolpers; Clemens C Cyran; Michael Schmidt; Stefan Foerster; Konstantin Nikolaou; Maximilian F Reiser; Peter Bartenstein; Marcus Hacker Journal: J Nucl Med Date: 2009-09-16 Impact factor: 10.057
Authors: Su Jin Lee; Young Keun On; Eun Jeong Lee; Joon Young Choi; Byung-Tae Kim; Kyung-Han Lee Journal: J Nucl Med Date: 2008-07-16 Impact factor: 10.057
Authors: James H F Rudd; Kelly S Myers; Sameer Bansilal; Josef Machac; Mark Woodward; Valentin Fuster; Michael E Farkouh; Zahi A Fayad Journal: Circ Cardiovasc Imaging Date: 2009-01-26 Impact factor: 7.792
Authors: Elena Nobili; M Dolores Salvado; Lasse Folkersen; Laura Castiglioni; Jens Kastrup; Anders Wetterholm; Elena Tremoli; Göran K Hansson; Luigi Sironi; Jesper Z Haeggström; Anders Gabrielsen Journal: PLoS One Date: 2012-07-25 Impact factor: 3.240
Authors: Michał Podgórski; Maciej Kupczyk; Piotr Grzelak; Małgorzata Bocheńska-Marciniak; Michał Polguj; Piotr Kuna; Ludomir Stefańczyk Journal: Med Sci Monit Date: 2017-11-09
Authors: Attila Hamar; Zsolt Hascsi; Anita Pusztai; Monika Czókolyová; Edit Végh; Zsófia Pethő; Katalin Gulyás; Boglárka Soós; György Kerekes; Éva Szekanecz; Katalin Hodosi; Sándor Szántó; Gabriella Szűcs; Tamás Seres; Zoltán Szekanecz; Szilvia Szamosi Journal: RMD Open Date: 2021-11
Authors: Helga Pawelski; Uta Schnöckel; Dominik Kentrup; Alexander Grabner; Michael Schäfers; Stefan Reuter Journal: Biomed Res Int Date: 2014-04-01 Impact factor: 3.411
Authors: Izabela Tuleta; Dirk Skowasch; Florian Aurich; Nicolas Eckstein; Robert Schueler; Carmen Pizarro; Nadjib Schahab; Georg Nickenig; Christian Schaefer; Simon Pingel Journal: PLoS One Date: 2017-10-26 Impact factor: 3.240