Literature DB >> 23526162

Acantholactone, a new manzamine related alkaloid with an unprecedented δ-lactone and ε-lactam ring system.

Amir E Wahba1, Yann Fromentin, Yike Zou, Mark T Hamann.   

Abstract

A new manzamine-related alkaloid with unprecedented δ-lactone and ε-lactam rings called acantholactone (2), was isolated from the Indonesian sponge Acanthostrongylophora sp. The relative configuration of the two new ring systems was established through detailed analysis of NOESY correlations combined with molecular modeling studies. The absolute configuration of 2 was determined as 12S, 24R, 25R, 26R by comparing the computed electronic circular dichroism (ECD) spectra with experimental values.

Entities:  

Keywords:  Manzamine alkaloids

Year:  2012        PMID： 23526162      PMCID： PMC3601935          DOI： 10.1016/j.tetlet.2012.08.140

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  7 in total

Review 1.  The manzamine alkaloids.

Authors:  Jin-Feng Hu; Mark T Hamann; Russell Hill; Michelle Kelly
Journal:  Alkaloids Chem Biol       Date:  2003

2.  Manzamine B and E and ircinal A related alkaloids from an Indonesian Acanthostrongylophora sponge and their activity against infectious, tropical parasitic, and Alzheimer's diseases.

Authors:  Karumanchi V Rao; Marwa S Donia; Jiangnan Peng; Esther Garcia-Palomero; Diana Alonso; Ana Martinez; Miguel Medina; Scott G Franzblau; Babu L Tekwani; Shabana I Khan; Subagus Wahyuono; Kristine L Willett; Mark T Hamann
Journal:  J Nat Prod       Date:  2006-07       Impact factor: 4.050

3.  New manzamine alkaloids with potent activity against infectious diseases.

Authors:  K A El Sayed; M Kelly; U A Kara; K K Ang; I Katsuyama; D C Dunbar; A A Khan; M T Hamann
Journal:  J Am Chem Soc       Date:  2001-03-07       Impact factor: 15.419

4.  Three new manzamine alkaloids from a common Indonesian sponge and their activity against infectious and tropical parasitic diseases.

Authors:  Karumanchi V Rao; Noer Kasanah; Subagus Wahyuono; Babu L Tekwani; Raymond F Schinazi; Mark T Hamann
Journal:  J Nat Prod       Date:  2004-08       Impact factor: 4.050

5.  Zamamidines A and B, new manzamine alkaloids from the sponge Amphimedon species.

Authors:  Yohei Takahashi; Takaaki Kubota; Jane Fromont; Jun'ichi Kobayashi
Journal:  Org Lett       Date:  2009-01-01       Impact factor: 6.005

6.  Manadomanzamines A and B: a novel alkaloid ring system with potent activity against mycobacteria and HIV-1.

Authors:  Jiangnan Peng; Jin-Feng Hu; Abul B Kazi; Ze Li; Mitchell Avery; Olivier Peraud; Russell T Hill; Scott G Franzblau; Fangqiu Zhang; Raymond F Schinazi; Susan S Wirtz; Phillip Tharnish; Michelle Kelly; Subagus Wahyuono; Mark T Hamann
Journal:  J Am Chem Soc       Date:  2003-11-05       Impact factor: 15.419

Review 7.  The manzamines as an example of the unique structural classes available for the discovery and optimization of infectious disease controls based on marine natural products.

Authors:  Mark T Hamann
Journal:  Curr Pharm Des       Date:  2007       Impact factor: 3.116
  7 in total
  3 in total

Review 1.  Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity.

Authors:  Hanan I Althagbi; Walied M Alarif; Khalid O Al-Footy; Ahmed Abdel-Lateff
Journal:  Mar Drugs       Date:  2020-07-17       Impact factor: 5.118

Review 2.  Marine Indole Alkaloids.

Authors:  Natalie Netz; Till Opatz
Journal:  Mar Drugs       Date:  2015-08-06       Impact factor: 5.118

3.  RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study.

Authors:  Alejandro M S Mayer; Mary L Hall; Joseph Lach; Jonathan Clifford; Kevin Chandrasena; Caitlin Canton; Maria Kontoyianni; Yeun-Mun Choo; Dev Karan; Mark T Hamann
Journal:  Mar Drugs       Date:  2021-09-07       Impact factor: 5.118
  3 in total

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