RATIONALE: The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. OBJECTIVES: The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) concentrations on COPD morbidity in a periurban community. METHODS: Former smokers with COPD were recruited and indoor air was monitored over a 1-week period in the participant's bedroom and main living area at baseline, 3 months, and 6 months. At each visit, participants completed spirometry and questionnaires assessing respiratory symptoms. Exacerbations were assessed by questionnaires administered at clinic visits and monthly telephone calls. MEASUREMENTS AND MAIN RESULTS: Participants (n = 84) had moderate or severe COPD with a mean FEV1 of 48.6% predicted. The mean (± SD) indoor PM(2.5) and NO(2) concentrations were 11.4 ± 13.3 µg/m(3) and 10.8 ± 10.6 ppb in the bedroom, and 12.2 ± 12.2 µg/m(3) and 12.2 ± 11.8 ppb in the main living area. Increases in PM(2.5) concentrations in the main living area were associated with increases in respiratory symptoms, rescue medication use, and risk of severe COPD exacerbations. Increases in NO(2) concentrations in the main living area were independently associated with worse dyspnea. Increases in bedroom NO(2) concentrations were associated with increases in nocturnal symptoms and risk of severe COPD exacerbations. CONCLUSIONS: Indoor pollutant exposure, including PM(2.5) and NO(2), was associated with increased respiratory symptoms and risk of COPD exacerbation. Future investigations should include intervention studies that optimize indoor air quality as a novel therapeutic approach to improving COPD health outcomes.
RATIONALE: The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. OBJECTIVES: The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) concentrations on COPD morbidity in a periurban community. METHODS: Former smokers with COPD were recruited and indoor air was monitored over a 1-week period in the participant's bedroom and main living area at baseline, 3 months, and 6 months. At each visit, participants completed spirometry and questionnaires assessing respiratory symptoms. Exacerbations were assessed by questionnaires administered at clinic visits and monthly telephone calls. MEASUREMENTS AND MAIN RESULTS:Participants (n = 84) had moderate or severe COPD with a mean FEV1 of 48.6% predicted. The mean (± SD) indoor PM(2.5) and NO(2) concentrations were 11.4 ± 13.3 µg/m(3) and 10.8 ± 10.6 ppb in the bedroom, and 12.2 ± 12.2 µg/m(3) and 12.2 ± 11.8 ppb in the main living area. Increases in PM(2.5) concentrations in the main living area were associated with increases in respiratory symptoms, rescue medication use, and risk of severe COPD exacerbations. Increases in NO(2) concentrations in the main living area were independently associated with worse dyspnea. Increases in bedroom NO(2) concentrations were associated with increases in nocturnal symptoms and risk of severe COPD exacerbations. CONCLUSIONS: Indoor pollutant exposure, including PM(2.5) and NO(2), was associated with increased respiratory symptoms and risk of COPD exacerbation. Future investigations should include intervention studies that optimize indoor air quality as a novel therapeutic approach to improving COPD health outcomes.
Authors: Christopher C Daigle; David C Chalupa; F Raymond Gibb; Paul E Morrow; Günter Oberdörster; Mark J Utell; Mark W Frampton Journal: Inhal Toxicol Date: 2003-05 Impact factor: 2.724
Authors: Mark D Eisner; Carlos Iribarren; Edward H Yelin; Stephen Sidney; Patricia P Katz; Gabriela Sanchez; Paul D Blanc Journal: Int J Chron Obstruct Pulmon Dis Date: 2009-05-07
Authors: Benjamin J Apelberg; Lisa M Hepp; Erika Avila-Tang; Lara Gundel; S Katharine Hammond; Melbourne F Hovell; Andrew Hyland; Neil E Klepeis; Camille C Madsen; Ana Navas-Acien; James Repace; Jonathan M Samet; Patrick N Breysse Journal: Tob Control Date: 2012-09-04 Impact factor: 7.552
Authors: A J Chauhan; Hazel M Inskip; Catherine H Linaker; Sandra Smith; Jacqueline Schreiber; Sebastian L Johnston; Stephen T Holgate Journal: Lancet Date: 2003-06-07 Impact factor: 79.321
Authors: Meredith C McCormack; Laura M Paulin; Christine E Gummerson; Roger D Peng; Gregory B Diette; Nadia N Hansel Journal: Eur Respir J Date: 2017-06-29 Impact factor: 16.671
Authors: L M Paulin; G B Diette; M Scott; M C McCormack; E C Matsui; J Curtin-Brosnan; D L Williams; A Kidd-Taylor; M Shea; P N Breysse; N N Hansel Journal: Indoor Air Date: 2014-01-11 Impact factor: 5.770
Authors: Meredith C McCormack; Andrew J Belli; Darryn Waugh; Elizabeth C Matsui; Roger D Peng; D'Ann L Williams; Laura Paulin; Anik Saha; Charles M Aloe; Gregory B Diette; Patrick N Breysse; Nadia N Hansel Journal: Ann Am Thorac Soc Date: 2016-12