Literature DB >> 23524963

WNT signaling in stem cell differentiation and tumor formation.

Hong Ouyang1, Yehong Zhuo, Kang Zhang.   

Abstract

Embryonic stem cells (ESCs) hold great therapeutic promise for the regeneration of functional cell types and clinical applications. However, tumorigenic potential of stem cells in a transplanted host remains a major obstacle. In this issue of the JCI, Cui and colleagues identified TCF7-mediated canonical WNT signaling as a critical determinant of both the tumorigenicity and therapeutic function of ESC-derived retinal progenitor cells (ESC-RPCs). Their findings suggested that addressing key extracellular signaling and related intrinsic factors will be essential for the successful use of ESC-derived progenitor transplantation.

Entities:  

Mesh：

Year:  2013        PMID： 23524963      PMCID： PMC3613938          DOI： 10.1172/JCI69324

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  13 in total

1.  Embryonic stem cell trials for macular degeneration: a preliminary report.

Authors:  Steven D Schwartz; Jean-Pierre Hubschman; Gad Heilwell; Valentina Franco-Cardenas; Carolyn K Pan; Rosaleen M Ostrick; Edmund Mickunas; Roger Gay; Irina Klimanskaya; Robert Lanza
Journal:  Lancet       Date:  2012-01-24       Impact factor: 79.321

2.  Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.

Authors:  Menno F Kielman; Maaret Rindapää; Claudia Gaspar; Nicole van Poppel; Cor Breukel; Sandra van Leeuwen; Makoto Mark Taketo; Scott Roberts; Ron Smits; Riccardo Fodde
Journal:  Nat Genet       Date:  2002-11-11       Impact factor: 38.330

3.  Stem cells and eye development.

Authors:  Kang Zhang; Sheng Ding
Journal:  N Engl J Med       Date:  2011-07-28       Impact factor: 91.245

4.  Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease.

Authors:  Daisuke Doi; Asuka Morizane; Tetsuhiro Kikuchi; Hirotaka Onoe; Takuya Hayashi; Toshiyuki Kawasaki; Makoto Motono; Yoshiki Sasai; Hidemoto Saiki; Masanori Gomi; Tatsuya Yoshikawa; Hideki Hayashi; Mizuya Shinoyama; Mohamed M Refaat; Hirofumi Suemori; Susumu Miyamoto; Jun Takahashi
Journal:  Stem Cells       Date:  2012-05       Impact factor: 6.277

5.  Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors.

Authors:  Wenlin Li; Woong Sun; Yu Zhang; Wanguo Wei; Rajesh Ambasudhan; Peng Xia; Maria Talantova; Tongxiang Lin; Janghwan Kim; Xiaolei Wang; Woon Ryoung Kim; Stuart A Lipton; Kang Zhang; Sheng Ding
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-27       Impact factor: 11.205

6.  WNT signaling determines tumorigenicity and function of ESC-derived retinal progenitors.

Authors:  Lu Cui; Yuan Guan; Zepeng Qu; Jingfa Zhang; Bing Liao; Bo Ma; Jiang Qian; Dangsheng Li; Weiye Li; Guo-Tong Xu; Ying Jin
Journal:  J Clin Invest       Date:  2013-03-25       Impact factor: 14.808

7.  Modeling early retinal development with human embryonic and induced pluripotent stem cells.

Authors:  Jason S Meyer; Rebecca L Shearer; Elizabeth E Capowski; Lynda S Wright; Kyle A Wallace; Erin L McMillan; Su-Chun Zhang; David M Gamm
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-25       Impact factor: 11.205

8.  Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.

Authors:  Deepak A Lamba; Juliane Gust; Thomas A Reh
Journal:  Cell Stem Cell       Date:  2009-01-09       Impact factor: 24.633

9.  Genome-wide methylation profiles reveal quantitative views of human aging rates.

Authors:  Gregory Hannum; Justin Guinney; Ling Zhao; Li Zhang; Guy Hughes; SriniVas Sadda; Brandy Klotzle; Marina Bibikova; Jian-Bing Fan; Yuan Gao; Rob Deconde; Menzies Chen; Indika Rajapakse; Stephen Friend; Trey Ideker; Kang Zhang
Journal:  Mol Cell       Date:  2012-11-21       Impact factor: 17.970

10.  Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors.

Authors:  Emma L West; Anai Gonzalez-Cordero; Claire Hippert; Fumitaka Osakada; Juan Pedro Martinez-Barbera; Rachael A Pearson; Jane C Sowden; Masayo Takahashi; Robin R Ali
Journal:  Stem Cells       Date:  2012-07       Impact factor: 6.277
View more
  5 in total

1.  TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling Via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.

Authors:  Youn-Sang Jung; Sabrina A Stratton; Sung Ho Lee; Moon-Jong Kim; Sohee Jun; Jie Zhang; Biyun Zheng; Christopher L Cervantes; Jong-Ho Cha; Michelle C Barton; Jae-Il Park
Journal:  Hepatology       Date:  2020-11-17       Impact factor: 17.425

Review 2.  Mutual regulation of the Hippo/Wnt/LPA/TGF‑β signaling pathways and their roles in glaucoma (Review).

Authors:  Xin Wang; Guoli Huai; Hailian Wang; Yuande Liu; Ping Qi; Wei Shi; Jie Peng; Hongji Yang; Shaoping Deng; Yi Wang
Journal:  Int J Mol Med       Date:  2017-12-29       Impact factor: 4.101

3.  Ethyl Pyruvate-Derived Transdifferentiation of Astrocytes to Oligodendrogenesis in Cuprizone-Induced Demyelinating Model.

Authors:  Yan He; Jun An; Jun-Jun Yin; Qiang Miao; Ruo-Xuan Sui; Qing-Xian Han; Zhi-Bin Ding; Jian-Jun Huang; Cun-Gen Ma; Bao-Guo Xiao
Journal:  Neurotherapeutics       Date:  2020-11-02       Impact factor: 7.620

4.  Antagonizing Wnt pathway in diabetic retinopathy.

Authors:  Ling Zhao; Sherrina H Patel; Jacqueline Pei; Kang Zhang
Journal:  Diabetes       Date:  2013-12       Impact factor: 9.461

5.  Wnt/β-catenin pathway regulates cementogenic differentiation of adipose tissue-deprived stem cells in dental follicle cell-conditioned medium.

Authors:  Na Liu; Bin Gu; Ning Liu; Xin Nie; Bo Zhang; Xia Zhou; Manjing Deng
Journal:  PLoS One       Date:  2014-05-07       Impact factor: 3.240
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.