BACKGROUND: Apolipoprotein E (apoE) levels have been shown to be elevated in pleural effusion of patients with non-small cell lung cancer (NSCLC). However, the diagnostic value of apoE in pleural effusion in NSCLC has not been well validated and established. METHODS: Samples of malignant pleural effusions (MPE) and benign effusions were collected and analyzed for apoE, tumor markers, and other biochemical changes. RESULTS: ApoE levels were significantly higher in MPE (n=160) than in benign pleural effusions (n=40). They were higher in adenocarcinoma-associated MPE than in squamous cell carcinoma- and large cell carcinoma-associated MPE. The receiver operating characteristic curve showed that the sensitivity and specificity of apoE for the diagnosis of MPE were 87.5% and 85.3%, respectively, at the cutoff 105 ng/ml, and the area under the curve (AUC) was 0.748. For the diagnosis of adenocarcinoma-associated MPE, apoE achieved sensitivity and specificity of 70.8% and 83.30%, respectively, and the AUC was the highest of all the markers. CONCLUSIONS: ApoE levels are significantly increased in the pleural effusion of patients with NSCLC. Increased concentration of apoE in a pleural effusion is a potential marker for the diagnosis of MPE as well as for differential diagnosis of MPE in NSCLC.
BACKGROUND:Apolipoprotein E (apoE) levels have been shown to be elevated in pleural effusion of patients with non-small cell lung cancer (NSCLC). However, the diagnostic value of apoE in pleural effusion in NSCLC has not been well validated and established. METHODS: Samples of malignant pleural effusions (MPE) and benign effusions were collected and analyzed for apoE, tumor markers, and other biochemical changes. RESULTS:ApoE levels were significantly higher in MPE (n=160) than in benign pleural effusions (n=40). They were higher in adenocarcinoma-associated MPE than in squamous cell carcinoma- and large cell carcinoma-associated MPE. The receiver operating characteristic curve showed that the sensitivity and specificity of apoE for the diagnosis of MPE were 87.5% and 85.3%, respectively, at the cutoff 105 ng/ml, and the area under the curve (AUC) was 0.748. For the diagnosis of adenocarcinoma-associated MPE, apoE achieved sensitivity and specificity of 70.8% and 83.30%, respectively, and the AUC was the highest of all the markers. CONCLUSIONS:ApoE levels are significantly increased in the pleural effusion of patients with NSCLC. Increased concentration of apoE in a pleural effusion is a potential marker for the diagnosis of MPE as well as for differential diagnosis of MPE in NSCLC.
Authors: Xianglan Yao; Elizabeth M Gordon; Debbie M Figueroa; Amisha V Barochia; Stewart J Levine Journal: Am J Respir Cell Mol Biol Date: 2016-08 Impact factor: 6.914
Authors: Jose D Santotoribio; Consuelo Cañavate-Solano; Angela Garcia-de la Torre; Luis Del Valle-Vazquez; Francisco Arce-Matute; Juan F Cuadros-Muñoz; Maria J Sanchez del Pino; Manuel J Bandez-Ruiz; Carmen Piñuela-Rojas; Santiago Perez-Ramos Journal: Tumour Biol Date: 2015-05-09
Authors: Jose D Santotoribio; Luis Del Valle-Vazquez; Angela García-de la Torre; Daniel Del Castillo-Otero; Juan-Bosco Lopez-Saez; Maria J Sanchez Del Pino Journal: PLoS One Date: 2019-09-24 Impact factor: 3.240