INTRODUCTION: In the conservative treatment of burns, rapid wound healing is desirable to obtain good a esthetic and functional results. The aim of this study was to compare the efficacy of 1% Silversulfadiazine (SSD/Flammazine(®)) and an enzyme alginogel (Flaminal(®) or Flaminal(®) Forte) on the healing of superficial and intermediate partial thickness burns. METHODS: In this retrospective cohort study comparable burn wounds treated with Flaminal(®) or with 1% SSD were included. Outcome parameters included: length of hospital stay, bacterial burden and time to wound closure. Significance was tested using SPSS package. RESULTS: 44 wounds in the Flaminal(®) group, and 39 wounds in the 1% SSD group were included. Wounds treated with Flaminal(®) showed a significantly higher bacterial load (p=0.024) and contained significantly more bacterial species (p=0.010) but showed a significantly shorter healing time of 17 vs. 24 days (p<0.0001). CONCLUSION: A significantly shorter healing time was demonstrated in partial thickness burn wounds treated with Flaminal(®) versus 1% SSD, which may lead to a shorter length of hospital stay and better scar quality. The possibility of accurate burn depth assessment and the results in this study corroborate the change in treatment protocol made in the year 2000 when we switched from 1% SSD to Flaminal(®).
INTRODUCTION: In the conservative treatment of burns, rapid wound healing is desirable to obtain good a esthetic and functional results. The aim of this study was to compare the efficacy of 1% Silversulfadiazine (SSD/Flammazine(®)) and an enzyme alginogel (Flaminal(®) or Flaminal(®) Forte) on the healing of superficial and intermediate partial thickness burns. METHODS: In this retrospective cohort study comparable burn wounds treated with Flaminal(®) or with 1% SSD were included. Outcome parameters included: length of hospital stay, bacterial burden and time to wound closure. Significance was tested using SPSS package. RESULTS: 44 wounds in the Flaminal(®) group, and 39 wounds in the 1% SSD group were included. Wounds treated with Flaminal(®) showed a significantly higher bacterial load (p=0.024) and contained significantly more bacterial species (p=0.010) but showed a significantly shorter healing time of 17 vs. 24 days (p<0.0001). CONCLUSION: A significantly shorter healing time was demonstrated in partial thickness burn wounds treated with Flaminal(®) versus 1% SSD, which may lead to a shorter length of hospital stay and better scar quality. The possibility of accurate burn depth assessment and the results in this study corroborate the change in treatment protocol made in the year 2000 when we switched from 1% SSD to Flaminal(®).
Authors: María Florencia Sanchez; Susana Andrea Breda; Elio Andrés Soria; Luis Ignacio Tártara; Rubén Hilario Manzo; María Eugenia Olivera Journal: Drug Deliv Transl Res Date: 2018-10 Impact factor: 4.617
Authors: Zjir M Rashaan; Pieta Krijnen; Kelly Aa Kwa; Margriet E van Baar; Roelf S Breederveld; M Elske van den Akker-van Marle Journal: Wound Repair Regen Date: 2020-02-11 Impact factor: 3.617
Authors: Zjir M Rashaan; Pieta Krijnen; Kelly A A Kwa; Cornelis H van der Vlies; Inger B Schipper; Roelf S Breederveld Journal: Wound Repair Regen Date: 2019-02-11 Impact factor: 3.617
Authors: María Florencia Sanchez; María Laura Guzman; Jesica Flores-Martín; Mariano Cruz Del Puerto; Carlos Laino; Elio Andrés Soria; Ana Carolina Donadio; Susana Genti-Raimondi; María Eugenia Olivera Journal: Sci Rep Date: 2022-09-26 Impact factor: 4.996
Authors: Zjir M Rashaan; Pieta Krijnen; M Elske van den Akker-van Marle; Margriet E van Baar; Adrianus F P Vloemans; Jan Dokter; Fenike R H Tempelman; Cees H van der Vlies; Roelf S Breederveld Journal: Trials Date: 2016-03-05 Impact factor: 2.279