| Literature DB >> 23522931 |
Anne Y Y Chan1, Larry Baum, Nelson L S Tang, Christine Y K Lau, Ping Wing Ng, Kwok Fai Hui, Yoshi Mizuno, Justin Y Kwan, Vincent C T Mok, Sheng-Han Kuo.
Abstract
The association between idiopathic Parkinson's disease (PD) and the ATP13A2 (PARK9) Ala746Thr variant, associated with Kufor-Rakeb syndrome, is controversial. We investigated this association in 69 patients with early onset PD (EOPD; ≦50 years of age), 192 patients with late onset PD (LOPD; >50 years of age), and 180 healthy controls in the Chinese population in Hong Kong. The presence of the Ala746Thr variant in the ATP13A2 locus was examined in all participants. We detected the heterozygous Ala746Thr variant in one healthy control (0.6%), one patient with EOPD (1.4%, p=0.50), and one patient with LOPD (0.5%, p=0.96). We suggest that the ATP13A2 Ala746Thr variant is not a common risk factor for PD in the Chinese population in Hong Kong.Entities:
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Year: 2013 PMID： 23522931 PMCID： PMC4209840 DOI： 10.1016/j.jocn.2012.05.052
Source DB: PubMed Journal: J Clin Neurosci ISSN： 0967-5868 Impact factor: 1.961