Literature DB >> 23522079

Which bovine endometrial cells are the source of and target for lysophosphatidic acid?

Dorota Boruszewska1, Ilona Kowalczyk-Zieba, Katarzyna Piotrowska-Tomala, Jean Sebastien Saulnier-Blache, Tomas Acosta, Dariusz Jan Skarzynski, Izabela Woclawek-Potocka.   

Abstract

The objective of the study was to examine which cultured endometrial cells are the source and which are the target for lysophosphatidic acid (LPA) in the bovine uterus. LPA concentration as well as mRNA and protein expressions of the enzymes responsible for LPA synthesis (phospholipase A2: PLA2, autotaxin: AX) were greater in epithelial than in stromal cells (P<0.05). In turn, mRNA and protein expression of LPA receptor (LPAR1) was lower in epithelial than in stromal cells (P<0.05). We suggest that LPA in bovine endometrium is produced mainly by epithelial cells and affects mostly stromal cells acting via LPAR1.
Copyright © 2013 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

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Year:  2013        PMID： 23522079     DOI： 10.1016/j.repbio.2013.01.166

Source DB:  PubMed          Journal:  Reprod Biol        ISSN： 1642-431X            Impact factor:   2.376


  4 in total

1.  Analysis of the transcriptome of bovine endometrial cells isolated by laser micro-dissection (1): specific signatures of stromal, glandular and luminal epithelial cells.

Authors:  Wiruntita Chankeaw; Sandra Lignier; Christophe Richard; Theodoros Ntallaris; Mariam Raliou; Yongzhi Guo; Damien Plassard; Claudia Bevilacqua; Olivier Sandra; Göran Andersson; Patrice Humblot; Gilles Charpigny
Journal:  BMC Genomics       Date:  2021-06-18       Impact factor: 3.969

2.  The effect of lysophosphatidic acid during in vitro maturation of bovine oocytes: embryonic development and mRNA abundances of genes involved in apoptosis and oocyte competence.

Authors:  Dorota Boruszewska; Ana Catarina Torres; Ilona Kowalczyk-Zieba; Patricia Diniz; Mariana Batista; Luis Lopes-da-Costa; Izabela Woclawek-Potocka
Journal:  Mediators Inflamm       Date:  2014-03-04       Impact factor: 4.711

Review 3.  Lysophosphatidic acid (LPA) signaling in human and ruminant reproductive tract.

Authors:  Izabela Wocławek-Potocka; Paulina Rawińska; Ilona Kowalczyk-Zieba; Dorota Boruszewska; Emilia Sinderewicz; Tomasz Waśniewski; Dariusz Jan Skarzynski
Journal:  Mediators Inflamm       Date:  2014-03-12       Impact factor: 4.711

4.  Lysophosphatidic acid signaling in late cleavage and blastocyst stage bovine embryos.

Authors:  Ana Catarina Torres; Dorota Boruszewska; Mariana Batista; Ilona Kowalczyk-Zieba; Patricia Diniz; Emilia Sinderewicz; Jean Sebastian Saulnier-Blache; Izabela Woclawek-Potocka; Luis Lopes-da-Costa
Journal:  Mediators Inflamm       Date:  2014-04-15       Impact factor: 4.711
  4 in total

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