Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Resurrecting the protein fold for disease intervention.

Literature DB >> 23521788

Resurrecting the protein fold for disease intervention.

Abstract

Because proteostasis networks manage the cellular proteome, their pharmacological manipulation might correct pathologies associated with numerous protein misfolding diseases. In this issue of Chemistry & Biology, Tong Ong and colleagues identify a novel biosynthetic juncture for glucocerebrosidase as a site for therapeutic intervention in Gaucher's disease.

Entities: Chemical Disease Gene Species

Year: 2013 PMID： 23521788 PMCID： PMC3658450 DOI： 10.1016/j.chembiol.2013.03.002

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

Keyword Cloud
References

10 in total

1. Conformational disease.

Authors: R R Kopito; D Ron
Journal: Nat Cell Biol Date: 2000-11 Impact factor: 28.824

Review 2. Dissecting glycoprotein quality control in the secretory pathway.

Authors: C M Cabral; Y Liu; R N Sifers
Journal: Trends Biochem Sci Date: 2001-10 Impact factor: 13.807

Review 3. Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease.

Authors: A R Sawkar; W D'Haeze; J W Kelly
Journal: Cell Mol Life Sci Date: 2006-05 Impact factor: 9.261

4. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts.

Authors: Derrick Sek Tong Ong; Ya-Juan Wang; Yun Lei Tan; John R Yates; Ting-Wei Mu; Jeffery W Kelly
Journal: Chem Biol Date: 2013-02-21

5. Principles that govern the folding of protein chains.

Authors: C B Anfinsen
Journal: Science Date: 1973-07-20 Impact factor: 47.728

6. Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix.

Authors: Aileen M Barnes; Wayne A Cabral; MaryAnn Weis; Elena Makareeva; Edward L Mertz; Sergey Leikin; David Eyre; Carlos Trujillo; Joan C Marini
Journal: Hum Mutat Date: 2012-07-16 Impact factor: 4.878

Resurrecting the protein fold for disease intervention.

1. Conformational disease.

Review 2. Dissecting glycoprotein quality control in the secretory pathway.

Review 3. Therapeutic strategies to ameliorate lysosomal storage disorders--a focus on Gaucher disease.

4. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts.

5. Principles that govern the folding of protein chains.

6. Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix.

7. Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis.

8. LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.

Review 9. Adapting proteostasis for disease intervention.

10. Defining human ERAD networks through an integrative mapping strategy.