Literature DB >> 23521768

Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.

Raffaele Pasceri1, David Siegel, David Ross, Christopher J Moody.   

Abstract

A range of 2-aminophenoxazin-3-ones has been prepared by oxidative cyclocondensation of 2-aminophenols, including the natural products exfoliazone and chandrananimycin A, both synthesized for the first time. The compounds were evaluated for their ability to inhibit indoleamine 2,3-dioxygenase. Compounds containing additional electron-withdrawing carboxylate groups, such as cinnabarinic acid, showed modest inhibitory activity with a dose response.

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Year:  2013        PMID： 23521768     DOI： 10.1021/jm400049z

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  6 in total

1.  The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia.

Authors:  Martina Ulivieri; Joanna Monika Wierońska; Luana Lionetto; Katiuscia Martinello; Paulina Cieslik; Agnieszka Chocyk; Martina Curto; Luisa Di Menna; Luisa Iacovelli; Anna Traficante; Francesca Liberatore; Giada Mascio; Nico Antenucci; Giuseppe Giannino; Matteo Vergassola; Anna Pittaluga; Valeria Bruno; Giuseppe Battaglia; Sergio Fucile; Maurizio Simmaco; Ferdinando Nicoletti; Andrzej Pilc; Francesco Fazio
Journal:  Schizophr Bull       Date:  2020-12-01       Impact factor: 9.306

2.  Enantioselective total syntheses of plectosphaeroic acids B and C.

Authors:  Salman Y Jabri; Larry E Overman
Journal:  J Org Chem       Date:  2013-08-27       Impact factor: 4.354

Review 3.  Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Authors:  Xiu-Xiu Wang; Si-Yu Sun; Qing-Qing Dong; Xiao-Xiang Wu; Wei Tang; Ya-Qun Xing
Journal:  Medchemcomm       Date:  2019-08-15       Impact factor: 3.597

4.  Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1.

Authors:  Saurav Paul; Ashalata Roy; Suman Jyoti Deka; Subhankar Panda; Gopal Narayan Srivastava; Vishal Trivedi; Debasis Manna
Journal:  Medchemcomm       Date:  2017-06-20       Impact factor: 3.597

Review 5.  Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors.

Authors:  Bilal Zulfiqar; Amnah Mahroo; Kaenat Nasir; Rai Khalid Farooq; Nasir Jalal; Muhammad Usman Rashid; Kashif Asghar
Journal:  Onco Targets Ther       Date:  2017-01-21       Impact factor: 4.147

Review 6.  Pharmacological Activities of Aminophenoxazinones.

Authors:  Jesús G Zorrilla; Carlos Rial; Daniel Cabrera; José M G Molinillo; Rosa M Varela; Francisco A Macías
Journal:  Molecules       Date:  2021-06-07       Impact factor: 4.411
  6 in total

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