BACKGROUND: Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach. METHODS: The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo questionnaire were prospectively validated. RESULTS: Seventy-five PD patients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%). CONCLUSIONS: A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.
BACKGROUND:Rapid eye movement (REM) sleep behavior disorder (RBD) is present in around 40% of Parkinson's disease (PD) patients. Definitive diagnosis requires a polysomnogram, but that is costly, time intensive, and not practical for large-scale studies. Therefore, we assessed using a questionnaire-based diagnostic approach. METHODS: The patient-administered RBD questionnaire and bed-partner-administered question 1 of the Mayo questionnaire were prospectively validated. RESULTS: Seventy-five PDpatients (51 male, 68 Hoehn and Yahr stages I and II) participated. Forty-eight had a clinical history of RBD. Sensitivity was 100% (95% CI, 86.3%-100%) when a combination of both questionnaires was compared with the gold standard of polysomnogram-confirmed RBD. Among those who achieved REM sleep (n=65), specificity was highest for the patient questionnaire used alone, at 82.4% (95% CI, 64.8%-92.6%). CONCLUSIONS: A combination of patient and bed-partner questionnaires is a useful tool to detect RBD.
Authors: Lama M Chahine; Shilpa R Kauta; Joseph T Daley; Charles R Cantor; Nabila Dahodwala Journal: Parkinsonism Relat Disord Date: 2014-04-18 Impact factor: 4.891
Authors: Claustre Pont-Sunyer; Alex Iranzo; Carles Gaig; Ana Fernández-Arcos; Dolores Vilas; Francesc Valldeoriola; Yaroslau Compta; Ruben Fernández-Santiago; Manel Fernández; Angels Bayés; Matilde Calopa; Pilar Casquero; Oriol de Fàbregues; Serge Jaumà; Victor Puente; Manel Salamero; Maria José Martí; Joan Santamaría; Eduard Tolosa Journal: PLoS One Date: 2015-07-15 Impact factor: 3.240
Authors: Michal Rolinski; Konrad Szewczyk-Krolikowski; Paul R Tomlinson; Kannan Nithi; Kevin Talbot; Yoav Ben-Shlomo; Michele Tm Hu Journal: J Neurol Neurosurg Psychiatry Date: 2013-11-01 Impact factor: 10.154