Literature DB >> 23519321

Mechanisms of disease: is mitochondrial function altered in heart failure?

Dale J Hamilton1.   

Abstract

The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.

Entities:  

Keywords:  heart failure; mitochondria; myocardial energetics; oxidative phosphorylation; oximetry; respiratory capacity

Mesh：

Year:  2013        PMID： 23519321      PMCID： PMC3600884          DOI： 10.14797/mdcj-9-1-44

Source DB:  PubMed          Journal:  Methodist Debakey Cardiovasc J        ISSN： 1947-6108


  30 in total

1.  Population impact of heart failure and the most common forms of cancer: a study of 1 162 309 hospital cases in Sweden (1988 to 2004).

Authors:  Simon Stewart; Inger Ekman; Tor Ekman; Anders Odén; Annika Rosengren
Journal:  Circ Cardiovasc Qual Outcomes       Date:  2010-10-05

2.  Calcium orchestrates apoptosis.

Authors:  Mark P Mattson; Sic L Chan
Journal:  Nat Cell Biol       Date:  2003-12       Impact factor: 28.824

Review 3.  Myocardial substrate metabolism in the normal and failing heart.

Authors:  William C Stanley; Fabio A Recchia; Gary D Lopaschuk
Journal:  Physiol Rev       Date:  2005-07       Impact factor: 37.312

Review 4.  The failing heart--an engine out of fuel.

Authors:  Stefan Neubauer
Journal:  N Engl J Med       Date:  2007-03-15       Impact factor: 91.245

Review 5.  Energy metabolism in heart failure and remodelling.

Authors:  Joanne S Ingwall
Journal:  Cardiovasc Res       Date:  2008-11-05       Impact factor: 10.787

6.  Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation.

Authors:  R Moreno-Sánchez; B A Hogue; R G Hansford
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

7.  Bidirectional regulation of Ca2+ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes.

Authors:  Yuan Yan; Jie Liu; Chaoliang Wei; Kaitao Li; Wenjun Xie; Yanru Wang; Heping Cheng
Journal:  Cardiovasc Res       Date:  2007-10-25       Impact factor: 10.787

8.  Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart.

Authors:  Ethan J Anderson; Alan P Kypson; Evelio Rodriguez; Curtis A Anderson; Eric J Lehr; P Darrell Neufer
Journal:  J Am Coll Cardiol       Date:  2009-11-10       Impact factor: 24.094

9.  Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study.

Authors:  Joshua M Hare; Brian Mangal; Joanne Brown; Charles Fisher; Ronald Freudenberger; Wilson S Colucci; Douglas L Mann; Peter Liu; Michael M Givertz; Richard P Schwarz
Journal:  J Am Coll Cardiol       Date:  2008-06-17       Impact factor: 24.094

10.  Creatine supplementation in chronic heart failure increases skeletal muscle creatine phosphate and muscle performance.

Authors:  A Gordon; E Hultman; L Kaijser; S Kristjansson; C J Rolf; O Nyquist; C Sylvén
Journal:  Cardiovasc Res       Date:  1995-09       Impact factor: 10.787
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