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Literature DB >> 23519014

The role of B-cells in heart failure.

Andrea M Cordero-Reyes¹, Keith A Youker, Guillermo Torre-Amione.

Abstract

Heart failure is a complex disease that has great impact on morbidity and mortality in the general population. No recent therapies have proven to be effective; however, the discovery of new potential pathophysiological mechanisms involved in heart failure expression and progression could offer novel therapeutic strategies. A number of studies have shown that the immune system may be a central mediator in the development and progression of heart failure, and here we describe how the B-cell and B-cell-mediated pathways play specific roles in the heart failure state. Therapies aimed at B-cells, either blocking antibody production or inactivating B-cell function, may suggest potential new treatment strategies.

Entities: Disease

Keywords: B-cell; auto-antibodies; cardiomyopathy; humoral; immune system

Mesh：

Year: 2013 PMID： 23519014 PMCID： PMC3600879 DOI： 10.14797/mdcj-9-1-15

Source DB: PubMed Journal: Methodist Debakey Cardiovasc J ISSN： 1947-6108

51 in total

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