Literature DB >> 23518927

Minireview: Obesity and breast cancer: a tale of inflammation and dysregulated metabolism.

Evan R Simpson1, Kristy A Brown.   

Abstract

In addition to the spectrum of conditions known collectively as the Metabolic Syndrome, obesity is now recognized to be associated with increased risk of several cancers including colon, endometrial, and breast cancer. Obesity and carcinogenesis share 2 characteristics in common. On the one hand, they involve inflammatory pathways, and on the other hand, they involve dysregulated metabolism. In this review we focus on postmenopausal breast cancer and discuss the metabolic and cellular mechanisms whereby obesity and breast cancer are related. Because a majority of postmenopausal breast tumors are estrogen responsive, we include a discussion of the action of obesity-related factors on estrogen formation within the breast.

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Year:  2013        PMID： 23518927      PMCID： PMC5416759          DOI： 10.1210/me.2013-1011

Source DB:  PubMed          Journal:  Mol Endocrinol        ISSN： 0888-8809


  76 in total

1.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  Connecting threads: epigenetics and metabolism.

Authors:  Sayako Katada; Axel Imhof; Paolo Sassone-Corsi
Journal:  Cell       Date:  2012-01-20       Impact factor: 41.582

3.  p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

Authors:  Yossi Dagon; Elizabeth Hur; Bin Zheng; Kerry Wellenstein; Lewis C Cantley; Barbara B Kahn
Journal:  Cell Metab       Date:  2012-06-21       Impact factor: 27.287

Review 4.  Adipose tissue: the new endocrine organ? A review article.

Authors:  Susan E Wozniak; Laura L Gee; Mitchell S Wachtel; Eldo E Frezza
Journal:  Dig Dis Sci       Date:  2008-12-04       Impact factor: 3.199

Review 5.  Endocrine-related cancers and the role of AMPK.

Authors:  Kristy A Brown; Nirukshi U Samarajeewa; Evan R Simpson
Journal:  Mol Cell Endocrinol       Date:  2012-07-16       Impact factor: 4.102

6.  AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

Authors:  Russell G Jones; David R Plas; Sara Kubek; Monica Buzzai; James Mu; Yang Xu; Morris J Birnbaum; Craig B Thompson
Journal:  Mol Cell       Date:  2005-04-29       Impact factor: 17.970

Review 7.  The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

Authors:  Maria M Mihaylova; Reuben J Shaw
Journal:  Nat Cell Biol       Date:  2011-09-02       Impact factor: 28.824

8.  The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells.

Authors:  Yun Wang; Kai Woo Lee; Franky L Chan; Shiuan Chen; Lai K Leung
Journal:  Toxicol Sci       Date:  2006-04-11       Impact factor: 4.849

9.  A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription.

Authors:  S E Bulun; T M Price; J Aitken; M S Mahendroo; E R Simpson
Journal:  J Clin Endocrinol Metab       Date:  1993-12       Impact factor: 5.958

10.  SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.

Authors:  Thomas Porstmann; Claudio R Santos; Beatrice Griffiths; Megan Cully; Mary Wu; Sally Leevers; John R Griffiths; Yuen-Li Chung; Almut Schulze
Journal:  Cell Metab       Date:  2008-09       Impact factor: 27.287
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  30 in total

1.  Effect of a six-month yoga exercise intervention on fitness outcomes for breast cancer survivors.

Authors:  Daniel C Hughes; Nydia Darby; Krystle Gonzalez; Terri Boggess; Ruth M Morris; Amelie G Ramirez
Journal:  Physiother Theory Pract       Date:  2015       Impact factor: 2.279

2.  Obesity and thyroid cancer: is leptin the (only) link?

Authors:  Antonio Di Cristofano
Journal:  Endocrinology       Date:  2013-08       Impact factor: 4.736

3.  High-fat diet induced leptin and Wnt expression: RNA-sequencing and pathway analysis of mouse colonic tissue and tumors.

Authors:  Harrison M Penrose; Sandra Heller; Chloe Cable; Hani Nakhoul; Melody Baddoo; Erik Flemington; Susan E Crawford; Suzana D Savkovic
Journal:  Carcinogenesis       Date:  2017-03-01       Impact factor: 4.944

4.  Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients.

Authors:  S Jiralerspong; E S Kim; W Dong; L Feng; G N Hortobagyi; S H Giordano
Journal:  Ann Oncol       Date:  2013-06-21       Impact factor: 32.976

5.  Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations.

Authors:  Julia K Bird; Alayne G Ronnenberg; Sang-Woon Choi; Fangling Du; Joel B Mason; Zhenhua Liu
Journal:  J Nutr       Date:  2014-11-12       Impact factor: 4.798

6.  The influence of different calorie restriction protocols on serum pro-inflammatory cytokines, adipokines and IGF-I levels in female C57BL6 mice: short term and long term diet effects.

Authors:  Soner Dogan; Amitabha Ray; Margot P Cleary
Journal:  Meta Gene       Date:  2017-01-03

7.  Vitamin D mitigates the adverse effects of obesity on breast cancer in mice.

Authors:  Srilatha Swami; Aruna V Krishnan; Jasmaine Williams; Abhishek Aggarwal; Megan A Albertelli; Ronald L Horst; Brian J Feldman; David Feldman
Journal:  Endocr Relat Cancer       Date:  2016-01-27       Impact factor: 5.678

Review 8.  Cyclooxygenase-2 and the inflammogenesis of breast cancer.

Authors:  Randall E Harris; Bruce C Casto; Zachary M Harris
Journal:  World J Clin Oncol       Date:  2014-10-10

9.  Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes.

Authors:  Maria Theresa E Montales; Stepan B Melnyk; Frank A Simmen; Rosalia C M Simmen
Journal:  Carcinogenesis       Date:  2014-05-15       Impact factor: 4.944

10.  GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state.

Authors:  Geetanjali Sharma; Chelin Hu; Jonathan L Brigman; Gang Zhu; Helen J Hathaway; Eric R Prossnitz
Journal:  Endocrinology       Date:  2013-08-22       Impact factor: 4.736
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