| Literature DB >> 23518304 |
Yao-zuo Yuan1, Mei Zhang, Xia-Lei Fan, Chang-qin Hu, Shao-hong Jin, Ann Van Schepdael, Jos Hoogmartens, Erwin Adams.
Abstract
The characterization of impurities present in vertilmicin by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C18 column resistant to basic pH with an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS with an electrospray ionization (ESI) source in the positive ion mode which provides MS(n) capability. In total, 18 impurities were detected in a commercial sample. Eleven impurities described in this work were newly identified.Entities:
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Year: 2013 PMID： 23518304 DOI： 10.1016/j.jpba.2013.02.026
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935