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Literature DB >> 2351746

Deterioration induced by physiological concentration of calcium ions in skinned muscle fibres.

Abstract

The deteriorating effect of microM order of Ca2+ on skinned frog skeletal muscle fibres was studied from the view point of the digestion of proteins by calcium-activated neutral protease (CANP). Tension developed in solutions containing no MgATP (rigor solution) decreased irreversibly with the addition of Ca2+ in quantities of more than 0.1 microM. Low temperature was seen to suppress (Q10 greater than 4), and neutral pH to maximize, this decrease in tension. In rigor solution containing Ca2+, SDS electrophoresis indicated that a 95 k dalton component (alpha-actinin) was released from the fibre; electron micrography showed the disappearance of Z-lines. These results suggest that one of the causes for decrease in rigor tension is the proteolytic activity of CANP, and its inhibitors were shown to be quite useful in experiments on skinned fibre.

Entities: Chemical Gene

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Year: 1990 PMID： 2351746 DOI： 10.1007/bf01833324

Source DB: PubMed Journal: J Muscle Res Cell Motil ISSN： 0142-4319 Impact factor: 2.698

21 in total

1. Stages in fibre breakdown in Duchenne muscular dystrophy. An electron-microscopic study.

Authors: M J Cullen; J J Fulthorpe
Journal: J Neurol Sci Date: 1975-02 Impact factor: 3.181

2. Delayed degeneration of dystrophic and normal muscle cell cultures treated with pepstatin, leupeptin, and antipain.

Authors: E B McGowan; S A Shafiq; A Stracher
Journal: Exp Neurol Date: 1976-03 Impact factor: 5.330

3. The effects of a calcium dependent protease on the ultrastructure and contractile mechanics of skinned uterine smooth muscle.

Authors: J R Haeberle; S A Coolican; A Evan; D R Hathaway
Journal: J Muscle Res Cell Motil Date: 1985-06 Impact factor: 2.698

4. Localization of the parallel elastic components in frog skinned muscle fibers studied by the dissociation of the A- and I-bands.

Authors: H Higuchi; Y Umazume
Journal: Biophys J Date: 1985-07 Impact factor: 4.033

Review 5. Sarcomere-associated cytoskeletal lattices in striated muscle. Review and hypothesis.

Authors: K Wang
Journal: Cell Muscle Motil Date: 1985

6. The protein inhibitor of calcium-dependent proteases: purification from bovine heart and possible mechanisms of regulation.

Authors: R L Mellgren; T C Carr
Journal: Arch Biochem Biophys Date: 1983-09 Impact factor: 4.013

7. Canine cardiac calcium-dependent proteases: Resolution of two forms with different requirements for calcium.

Authors: R L Mellgren
Journal: FEBS Lett Date: 1980-01-01 Impact factor: 4.124

8. Removal of Z-lines and alpha-actinin from isolated myofibrils by a calcium-activated neutral protease.

Authors: M K Reddy; J D Etlinger; M Rabinowitz; D A Fischman; R Zak
Journal: J Biol Chem Date: 1975-06-10 Impact factor: 5.157

9. The use of A23187 to demonstrate the role of intracellular calcium in causing ultrastructural damage in mammalian muscle.

Authors: S J Publicover; C J Duncan; J L Smith
Journal: J Neuropathol Exp Neurol Date: 1978-09 Impact factor: 3.685

10. Width and lattice spacing in radially compressed frog skinned muscle fibres at various pH values, magnesium ion concentrations and ionic strengths.

Authors: Y Umazume; S Onodera; H Higuchi
Journal: J Muscle Res Cell Motil Date: 1986-06 Impact factor: 2.698

9 in total

Deterioration induced by physiological concentration of calcium ions in skinned muscle fibres.

1. Stages in fibre breakdown in Duchenne muscular dystrophy. An electron-microscopic study.

2. Delayed degeneration of dystrophic and normal muscle cell cultures treated with pepstatin, leupeptin, and antipain.

3. The effects of a calcium dependent protease on the ultrastructure and contractile mechanics of skinned uterine smooth muscle.

4. Localization of the parallel elastic components in frog skinned muscle fibers studied by the dissociation of the A- and I-bands.

Review 5. Sarcomere-associated cytoskeletal lattices in striated muscle. Review and hypothesis.

6. The protein inhibitor of calcium-dependent proteases: purification from bovine heart and possible mechanisms of regulation.

7. Canine cardiac calcium-dependent proteases: Resolution of two forms with different requirements for calcium.

8. Removal of Z-lines and alpha-actinin from isolated myofibrils by a calcium-activated neutral protease.

9. The use of A23187 to demonstrate the role of intracellular calcium in causing ultrastructural damage in mammalian muscle.

10. Width and lattice spacing in radially compressed frog skinned muscle fibres at various pH values, magnesium ion concentrations and ionic strengths.

1. Disruption of excitation-contraction coupling and titin by endogenous Ca2+-activated proteases in toad muscle fibres.

2. Skinning effects on skeletal muscle myowater probed by T2 relaxation of 1H-NMR.

3. Compliance of thin filaments in skinned fibers of rabbit skeletal muscle.

4. Rapid recovery following contraction-induced injury to in situ skeletal muscles in mdx mice.

5. Mechanical study of rat soleus muscle using caged ATP and X-ray diffraction: high ADP affinity of slow cross-bridges.

6. Myofibrillar ATPase activity in skinned human skeletal muscle fibres: fibre type and temperature dependence.

7. Functional characterization of the two isoforms of troponin C from the arthropod Balanus nubilus.

8. Mapping of the calpain proteolysis products of the junctional foot protein of the skeletal muscle triad junction.

9. Sarcoplasmic-reticulum biogenesis in contraction-inhibited skeletal-muscle cultures.