| Literature DB >> 23517410 |
David H Blakey1, Marc Lafontaine, Jocelyn Lavigne, Danny Sokolowski, Jean-Marc Philippe, Jean-Marc Sapori, Walter Biederbick, Regine Horre, Willi B Marzi, Hisayoshi Kondo, Yumiko Kuroki, Akira Namera, Tetsu Okumura, Miyako Yamamoto, Mikio Yashiki, Peter G Blain, David R Russell, Susan M Cibulsky, David A Jett.
Abstract
The Chemical Events Working Group of the Global Health Security Initiative has developed a flexible screening tool for chemicals that present a risk when accidentally or deliberately released into the atmosphere. The tool is generic, semi-quantitative, independent of site, situation and scenario, encompasses all chemical hazards (toxicity, flammability and reactivity), and can be easily and quickly implemented by non-subject matter experts using freely available, authoritative information. Public health practitioners and planners can use the screening tool to assist them in directing their activities in each of the five stages of the disaster management cycle.Entities:
Mesh:
Substances:
Year: 2013 PMID: 23517410 PMCID: PMC3751112 DOI: 10.1186/1471-2458-13-253
Source DB: PubMed Journal: BMC Public Health ISSN: 1471-2458 Impact factor: 3.295
Examples of HPV chemicals [1]
| benzene | chlorine | polyethylene | ammonia |
| ethylene | sodium carbonate | polypropylene | ammonium nitrate |
| methanol | sodium hydroxide | polystyrene | phosphate rock |
| propylene | sulphuric acid | polyvinyl chloride | phosphoric acid |
Examples of chemical incidents resulting in regulatory actions
| Nypro UK Ltd, Flixborough, UK | 1 Jun 1974 | Explosion and fire – release of 30 tonnes of cyclohexane resulting in a vapour cloud explosion | 28 killed; 89 injured, damage for several km | Influenced Seveso 1 content | [ |
| Led to the UK Health & Safety at Work Act & establishment of UK Health & Safety Executive | |||||
| Hoffmann LaRoche, Seveso, Italy | 10 Jul 1976 | Runaway thermal reaction – toxic and corrosive chemical cloud formed, containing phenols, sodium hydroxide, and ~2 kg of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) | Over 5,700 residents evacuated; 220,000 people under medical surveillance; 447 cases of skin lesions or chloracne; >3000 animals dead; 80,000 animals slaughtered; affected a 18 sq km area; 20 billion lire paid in compensation | Led to Seveso 1 Directive | [ |
| Union Carbide India Ltd, Bhopal, India | 3 Dec 1984 | Runaway reaction – 30–40 tonnes of methyl isocyanate released which drifted over a crowded working class neighbourhood; no warning for people within the area surrounding the plant | 2,500-6,000 deaths; >200,000 injured; >50,000 survivors experiencing chronic ailments such as pulmonary fibrosis, bronchial asthma, chronic obstructive pulmonary disease, emphysema, recurrent chest infections, keratopathy and corneal opacities | Led to changes in Seveso I thresholds and proximity to residential populations, influenced land use planning provisions | [ |
| Led to USA Emergency Planning & Community Right to Know Act & CMA CAER Program | |||||
| Sandoz, Basel, Switzerland | 1 Nov 1986 | Warehouse fire – 30 tonnes of chemicals released into air and water (dinitro-ortho-cresol, organochlorines, organophosphates, ~150 kg mercury) | Massive contamination of the Rhine, 500,000 fish killed; pollution travelled over 500 km | Extended Seveso I to include storage activities | [ |
| Phillips 66 Co, Pasadena, Texas, USA | 23 Oct 1989 | Explosion and fire – high density polyethylene production – release of >85,000 lbs of highly flammable process gases | 23 deaths; more than 130 injured; over $1 billion in losses | Triggered 1990 USA Clean Air Act & Risk Management Program (RMP) & Process Safety Management (PSM) process standards | [ |
| SE Fireworks, Enschede, The Netherlands | 13 May 2000 | Explosion and fire – 177 tonnes of fireworks exploded | 22 killed; 947 injured; 2000 homes destroyed | Led to changes to definition of explosives in Seveso II | [ |
| Aurul S.A., Baia Mara, Romania | 30 Jan 2000 | Breach in tailings dam – 100,000 m3 of cyanide rich tailings (cyanide plus heavy metals including copper) released into rivers feeding Danube and Black Sea | Contamination of water supply at 24 locations affecting 250,000 people; massive fish kill; destruction of aquatic species; pollution of ~ 200 km of river basin | Extended application of Seveso II | [ |
| Grande Paroisse, Toulouse, France | 21 Sep 2001 | Explosion and fire – 300–400 tonnes of downgraded ammonium nitrate | 30 deaths; 2,242 injured (20 seriously), 5,079 treated for stress; 25,000 homes damaged; 5 schools destroyed; 1,000 factories damaged; toxic chemicals leaked into river | Changed application of Seveso II with respect to ammonium nitrate | [ |
Severity of hazard criteria and scoring of chemicals
| ≤1 | 4 | Flammable gas or cryogenic material | 4 | Materials with instantaneous power density (IPD) of 1000 W/mL or greater @ 250°C; sensitive to localized thermal or mechanical shock at normal temperature and pressure | 4 |
| Liquid with flash point (FP) below 22.8°C and boiling point (BP) below 37°C | |||||
| | | Materials that spontaneously ignite when exposed to air | | | |
| >1, ≤10 | 3 | Liquids with FP below 22.8°C and BP at or above 37.8°C; or FP at or above 22.8°C and below 37.8°C | 3 | Materials with IPD at or above 100 W/mL and below 1000 W/mL @ 250°C; sensitive to thermal or mechanical shock at elevated temperature and pressure | 3 |
| >10, ≤100 | 2 | Liquids with FP at or above 37.8°C and below 93.4°C | 2 | Materials with IPD at or above 10 W/mL and below 100 W/mL @ 250°C | 2 |
| >100, ≤1000 | 1 | Liquids, solids, semi-solids with FP above 93.4°C | 1 | Materials with IPD at or above 0.01 W/mL and below 10 W/mL @ 250°C | 1 |
| >1000 | 0 | If assigned 0 by NFPA | 0 | Materials with IPD below 0.01 W/mL @ 250°C | 0 |
* See NFPA 704 for complete listing of criteria [30].
Severity of hazard classes and scoring
| 4 | 3 | 2 | 1 | 0 | |
| (highest score received in one of the 3 hazard categories: flammability, toxicity, reactivity) |
Vapour pressure scoring
| gas or pressurized liquid | gas or pressurized liquid | 6 |
| liquid, vp ≥ 50 | liquid, vp ≥ 376 | 5 |
| liquid, vp ≥ 10, <50 | liquid, vp ≥ 75.2, <376 | 4 |
| liquid/solid, vp ≥ 1, <10 | liquid/solid, vp ≥ 7.52, <75.2 | 3 |
| liquid/solid, vp ≥ 0.1, <1 | liquid/solid, vp ≥ 0.752, <7.52 | 2 |
| liquid/solid, vp <0.1 | liquid/solid, vp <0.752 | 1 |
Criteria for determining the availability of chemicals and scoring
| 5 | |
| 4 | |
| 3 | |
| not commercially available, | 2 |
| not commercially available, | 1 |
Probability of exposure classes and scoring
| 30-25 | 24-19 | 18-13 | 12-7 | 6-1 |
Figure 1Risk matrix.
Figure 2Example showing determination of risk for chemicals released into the atmosphere.
The role the public health community can play in the chemical disaster management cycle
| ▪ Identifying chemical hazards | ▪ Contributing to the design, set-up & maintenance of effective emergency response infrastructures | ▪ Supporting installation of chemical detection & alarm systems | ▪ Activating the public health aspects of the incident management system | ▪ Organizing health care, including mental health care, to treat victims & to support them throughout the recovery cycle |
| ▪ Conducting risk assessment | ▪ Contributing to the development of integrated chemical emergency plans | ▪ Establishing methods to detect & report covert chemical incidents | ▪ Making rapid assessments of incident control options | ▪ Undertaking risk & health outcome assessments |
| ▪ Determining health impact of all potential release scenarios | ▪ Developing public health chemical incident response plans | ▪ Developing chemical incident recognition training | ▪ Advising and alerting health care services | ▪ Implementing remediation and restoration actions |
| ▪ Communicating data on chemical hazards to the general public | ▪ Supporting the development of relevant databases | ▪ Developing diagnostic technologies for chemical exposures | ▪ Ensuring coordination & integration of public health response | ▪ Collecting and compiling epidemiological data |
| ▪ Supporting land use planning regulations | ▪ Preparing information on chemical hazards & countermeasures and communicating this information to the public | ▪ Providing phone and Internet connections to report incidents | ▪ Conducting a best outcome assessment for both immediate & long-term actions. | ▪ Evaluating emergency response |
| ▪ Supporting reduction in quantities of chemicals stored | ▪ Maintaining an inventory of existing medical countermeasures | ▪ Developing population health & environmental surveillance systems | ▪ Disseminating information and advice to responders, the public & the media | ▪ Tabulating and disseminating lessons learned |
| ▪ Supporting product substitution | ▪ Developing improved medical countermeasures | ▪ Developing incident alert systems | ▪ Registering all exposed individuals & collecting samples to estimate exposure | |
| ▪ Supporting improved plant & equipment design | ▪ Developing training programs | | ▪ Conducting epidemiological investigations | |
| ▪ Supporting increased security at chemical transport and storage facilities | ▪ Planning and participating in chemical incident exercises | | | |
| ▪ Supporting law enforcement and intelligence |