Literature DB >> 23517377

Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.

Vladimir Kravchenko1, Amanda L Garner, John Mathison, Alim Seit-Nebi, Jing Yu, Irina P Gileva, Richard Ulevitch, Kim D Janda.   

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of TRAIL-induced apoptosis and AHL-mediated inhibition of inflammation regulated by NF-κB signaling. This discovery unveils a previously unrecognized symbiotic link between bacteria and host immunosurveillance.

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Year:  2013        PMID： 23517377      PMCID： PMC3755046          DOI： 10.1021/cb4000184

Source DB:  PubMed          Journal:  ACS Chem Biol        ISSN： 1554-8929            Impact factor:   5.100


  25 in total

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Authors:  M Barkett; T D Gilmore
Journal:  Oncogene       Date:  1999-11-22       Impact factor: 9.867

Review 2.  Circuitry of nuclear factor kappaB signaling.

Authors:  Alexander Hoffmann; David Baltimore
Journal:  Immunol Rev       Date:  2006-04       Impact factor: 12.988

3.  Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death.

Authors:  Z G Liu; H Hsu; D V Goeddel; M Karin
Journal:  Cell       Date:  1996-11-01       Impact factor: 41.582

4.  N-(3-oxo-acyl)homoserine lactones signal cell activation through a mechanism distinct from the canonical pathogen-associated molecular pattern recognition receptor pathways.

Authors:  Vladimir V Kravchenko; Gunnar F Kaufmann; John C Mathison; David A Scott; Alexander Z Katz; Malcolm R Wood; Andrew P Brogan; Mandy Lehmann; Jenny M Mee; Kazunori Iwata; Qilin Pan; Colleen Fearns; Ulla G Knaus; Michael M Meijler; Kim D Janda; Richard J Ulevitch
Journal:  J Biol Chem       Date:  2006-08-07       Impact factor: 5.157

5.  Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.

Authors:  R J Moore; D M Owens; G Stamp; C Arnott; F Burke; N East; H Holdsworth; L Turner; B Rollins; M Pasparakis; G Kollias; F Balkwill
Journal:  Nat Med       Date:  1999-07       Impact factor: 53.440

6.  Achieving stability of lipopolysaccharide-induced NF-kappaB activation.

Authors:  Markus W Covert; Thomas H Leung; Jahlionais E Gaston; David Baltimore
Journal:  Science       Date:  2005-09-16       Impact factor: 47.728

7.  Safety and antitumor activity of recombinant soluble Apo2 ligand.

Authors:  A Ashkenazi; R C Pai; S Fong; S Leung; D A Lawrence; S A Marsters; C Blackie; L Chang; A E McMurtrey; A Hebert; L DeForge; I L Koumenis; D Lewis; L Harris; J Bussiere; H Koeppen; Z Shahrokh; R H Schwall
Journal:  J Clin Invest       Date:  1999-07       Impact factor: 14.808

8.  The Pseudomonas aeruginosa quorum-sensing signal molecule N-(3-oxododecanoyl)-L-homoserine lactone has immunomodulatory activity.

Authors:  G Telford; D Wheeler; P Williams; P T Tomkins; P Appleby; H Sewell; G S Stewart; B W Bycroft; D I Pritchard
Journal:  Infect Immun       Date:  1998-01       Impact factor: 3.441

9.  The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway.

Authors:  Elena Vikström; Karl-Eric Magnusson; Augustas Pivoriūnas
Journal:  Microbes Infect       Date:  2005-07-01       Impact factor: 2.700

10.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Authors:  A Poltorak; X He; I Smirnova; M Y Liu; C Van Huffel; X Du; D Birdwell; E Alejos; M Silva; C Galanos; M Freudenberg; P Ricciardi-Castagnoli; B Layton; B Beutler
Journal:  Science       Date:  1998-12-11       Impact factor: 47.728
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  3 in total

1.  Bifunctional Doscadenamides Activate Quorum Sensing in Gram-Negative Bacteria and Synergize with TRAIL to Induce Apoptosis in Cancer Cells.

Authors:  Xiao Liang; Qi-Yin Chen; Gustavo M Seabra; Susan Matthew; Jason C Kwan; Chenglong Li; Valerie J Paul; Hendrik Luesch
Journal:  J Nat Prod       Date:  2021-01-22       Impact factor: 4.050

Review 2.  Intra-Species and Inter-Kingdom Signaling of Legionella pneumophila.

Authors:  Ramon Hochstrasser; Hubert Hilbi
Journal:  Front Microbiol       Date:  2017-02-03       Impact factor: 5.640

3.  Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones.

Authors:  Josep Rayo; Rachel Gregor; Nicholas T Jacob; Rambabu Dandela; Luba Dubinsky; Alex Yashkin; Alexander Aranovich; Manikandan Thangaraj; Orna Ernst; Eran Barash; Sergey Malitsky; Bogdan I Florea; Bastiaan P Krom; Erik A C Wiemer; Valerie A Kickhoefer; Leonard H Rome; John C Mathison; Gunnar F Kaufmann; Herman S Overkleeft; Benjamin F Cravatt; Tsaffrir Zor; Kim D Janda; Richard J Ulevitch; Vladimir V Kravchenko; Michael M Meijler
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-23       Impact factor: 12.779
  3 in total

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