Literature DB >> 23517183

Interaction of anticancer ruthenium compounds with proteins: high-resolution X-ray structures and raman microscopy studies of the adduct between hen egg white lysozyme and AziRu.

Alessandro Vergara1, Gerardino D'Errico, Daniela Montesarchio, Gaetano Mangiapia, Luigi Paduano, Antonello Merlino.   

Abstract

The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu-protein adduct formation and of ligand exchange in the crystal state.

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Year:  2013        PMID： 23517183     DOI： 10.1021/ic4004142

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  7 in total

1.  Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c.).

Authors:  Luigi Messori; Maria Agostina Cinellu; Antonello Merlino
Journal:  ACS Med Chem Lett       Date:  2014-07-31       Impact factor: 4.345

Review 2.  Bioactivity and Development of Small Non-Platinum Metal-Based Chemotherapeutics.

Authors:  Maria Grazia Ferraro; Marialuisa Piccolo; Gabriella Misso; Rita Santamaria; Carlo Irace
Journal:  Pharmaceutics       Date:  2022-04-28       Impact factor: 6.525

Review 3.  Raman Spectroscopy and Aptamers for a Label-Free Approach: Diagnostic and Application Tools.

Authors:  Elisa Scatena; Silvia Baiguera; Costantino Del Gaudio
Journal:  J Healthc Eng       Date:  2019-04-28       Impact factor: 2.682

4.  Modification of Aβ Peptide Aggregation via Covalent Binding of a Series of Ru(III) Complexes.

Authors:  Luiza M F Gomes; Janaina C Bataglioli; Allison J Jussila; Jason R Smith; Charles J Walsby; Tim Storr
Journal:  Front Chem       Date:  2019-12-03       Impact factor: 5.221

Review 5.  Anticancer Ruthenium(III) Complexes and Ru(III)-Containing Nanoformulations: An Update on the Mechanism of Action and Biological Activity.

Authors:  Claudia Riccardi; Domenica Musumeci; Marco Trifuoggi; Carlo Irace; Luigi Paduano; Daniela Montesarchio
Journal:  Pharmaceuticals (Basel)       Date:  2019-09-26

6.  Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme.

Authors:  Domenico Loreto; Giarita Ferraro; Antonello Merlino
Journal:  Int J Mol Sci       Date:  2021-02-02       Impact factor: 5.923

7.  X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism.

Authors:  Aleksandar Bijelic; Sarah Theiner; Bernhard K Keppler; Annette Rompel
Journal:  J Med Chem       Date:  2016-06-07       Impact factor: 7.446
  7 in total

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