Literature DB >> 23515233

The impact of DaTscan on the diagnosis and management of movement disorders: A retrospective study.

Kimberly D Seifert1, Jonathan I Wiener.   

Abstract

BACKGROUND: The diagnosis of Parkinson's disease remains a challenge in patients who have abnormal symptoms or show a lack of response to medication. The imaging technique, DaTscan, can be used to visualize dopamine degeneration in the nigro-striatum, which is associated with Parkinsonian Syndrome. We examined the use of the DaTscan in diagnosis, confidence in diagnosis, and clinical management.
METHODS: Physicians of 125 patients were contacted to fill out a brief survey about changes in diagnosis, confidence of diagnosis, and clinical management after assessment with the DaTscan.
RESULTS: There was an overall increase in confidence of diagnosis with the results of the DaTscan. Physicians also stated that the DaTscan impacted their diagnosis in 68% of the patients, as well as an impact in the clinical management of 58% of the patients.
CONCLUSION: The DaTsan can be used as a tool to help diagnose Parkinsonian Syndrome in patients with unclear symptoms.

Entities:  

Keywords:  123I Ioflupane; DaTscan; parkinsonian syndrome

Year:  2013        PMID: 23515233      PMCID: PMC3601468     

Source DB:  PubMed          Journal:  Am J Neurodegener Dis        ISSN: 2165-591X


  31 in total

1.  Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group.

Authors:  T S Benamer; J Patterson; D G Grosset; J Booij; K de Bruin; E van Royen; J D Speelman; M H Horstink; H J Sips; R A Dierckx; J Versijpt; D Decoo; C Van Der Linden; D M Hadley; M Doder; A J Lees; D C Costa; S Gacinovic; W H Oertel; O Pogarell; H Hoeffken; K Joseph; K Tatsch; J Schwarz; V Ries
Journal:  Mov Disord       Date:  2000-05       Impact factor: 10.338

2.  How valid is the clinical diagnosis of Parkinson's disease in the community?

Authors:  A Schrag; Y Ben-Shlomo; N Quinn
Journal:  J Neurol Neurosurg Psychiatry       Date:  2002-11       Impact factor: 10.154

3.  Clinical impact of diagnostic SPET investigations with a dopamine re-uptake ligand.

Authors:  Annemette Løkkegaard; Lene M Werdelin; Lars Friberg
Journal:  Eur J Nucl Med Mol Imaging       Date:  2002-09-13       Impact factor: 9.236

4.  Impact of dopamine transporter SPECT using 123I-Ioflupane on diagnosis and management of patients with clinically uncertain Parkinsonian syndromes.

Authors:  Ana M Catafau; Eduardo Tolosa
Journal:  Mov Disord       Date:  2004-10       Impact factor: 10.338

5.  Prospective study of presynaptic dopaminergic imaging in patients with mild parkinsonism and tremor disorders: part 1. Baseline and 3-month observations.

Authors:  Hani T S Benamer; Wolfgang H Oertel; Jim Patterson; Donald M Hadley; Oliver Pogarell; H Höffken; A Gerstner; Donald G Grosset
Journal:  Mov Disord       Date:  2003-09       Impact factor: 10.338

Review 6.  Systematic review of incidence studies of Parkinson's disease.

Authors:  Dominique Twelves; Kate S M Perkins; Carl Counsell
Journal:  Mov Disord       Date:  2003-01       Impact factor: 10.338

7.  Accuracy of clinical diagnosis in parkinsonism--a prospective study.

Authors:  A H Rajput; B Rozdilsky; A Rajput
Journal:  Can J Neurol Sci       Date:  1991-08       Impact factor: 2.104

8.  Parametric mapping of [18F]FPCIT binding in early stage Parkinson's disease: a PET study.

Authors:  Y Ma; V Dhawan; M Mentis; T Chaly; P G Spetsieris; D Eidelberg
Journal:  Synapse       Date:  2002-08       Impact factor: 2.562

Review 9.  Role of dopamine transporter imaging in investigation of parkinsonian syndromes in routine clinical practice.

Authors:  Werner Poewe; Christoph Scherfler
Journal:  Mov Disord       Date:  2003-10       Impact factor: 10.338

10.  Changes in clinical management and diagnosis following DaTscan SPECT imaging in patients with clinically uncertain parkinsonian syndromes: a 12-week follow-up study.

Authors:  Andreas Kupsch; Nin Bajaj; Frederick Weiland; Antonio Tartaglione; Susanne Klutmann; Ronald Copp; Paul Sherwin; Ann Tate; Igor D Grachev
Journal:  Neurodegener Dis       Date:  2012-05-08       Impact factor: 2.977

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  16 in total

Review 1.  PET/SPECT imaging agents for neurodegenerative diseases.

Authors:  Lin Zhu; Karl Ploessl; Hank F Kung
Journal:  Chem Soc Rev       Date:  2014-10-07       Impact factor: 54.564

2.  DaT's Awesome: Hawai'i's First Dopamine Transporter (DaT) Nuclear Medicine Study.

Authors:  Eric J Royston; Yang-En Kao; Kevin M Nakamura
Journal:  Hawaii J Med Public Health       Date:  2017-11

3.  Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech.

Authors:  Zeynep Idil Seckin; Jennifer L Whitwell; Rene L Utianski; Hugo Botha; Farwa Ali; Joseph R Duffy; Heather M Clark; Mary M Machulda; Lennon G Jordan; Hoon-Ki Min; Val J Lowe; Keith A Josephs
Journal:  J Neurol       Date:  2020-05-09       Impact factor: 4.849

Review 4.  Biomarkers for Parkinson's Disease: Recent Advancement.

Authors:  Sharvari Lotankar; Kedar S Prabhavalkar; Lokesh K Bhatt
Journal:  Neurosci Bull       Date:  2017-09-21       Impact factor: 5.203

Review 5.  Clinical utility of DaTscan in patients with suspected Parkinsonian syndrome: a systematic review and meta-analysis.

Authors:  Danny Bega; Phillip H Kuo; Anastasia Chalkidou; Mariusz T Grzeda; Thomas Macmillan; Christine Brand; Zulfiqar H Sheikh; Angelo Antonini
Journal:  NPJ Parkinsons Dis       Date:  2021-05-24

6.  Differences in cause and 12-month follow-up outcome of parkinsonian symptoms in depressed older adults treated with antipsychotics: a case series.

Authors:  Anastasios Politis; Nikolaos Kokras; Michael Souvatzoglou; Kostas Siarkos; Panagiotis Toulas; Constantin Potagas; Theodoros Hatzipanagiotou; Georgios Limouris; Panagiotis Alexopoulos
Journal:  BMC Psychiatry       Date:  2021-06-03       Impact factor: 3.630

7.  Comparison between Different Intensity Normalization Methods in 123I-Ioflupane Imaging for the Automatic Detection of Parkinsonism.

Authors:  A Brahim; J Ramírez; J M Górriz; L Khedher; D Salas-Gonzalez
Journal:  PLoS One       Date:  2015-06-18       Impact factor: 3.240

8.  Imaging analysis of Parkinson's disease patients using SPECT and tractography.

Authors:  Seong-Jin Son; Mansu Kim; Hyunjin Park
Journal:  Sci Rep       Date:  2016-11-30       Impact factor: 4.379

Review 9.  Epigenetic Biomarkers for Parkinson's Disease: From Diagnostics to Therapeutics.

Authors:  Jennifer L Jakubowski; Viviane Labrie
Journal:  J Parkinsons Dis       Date:  2017       Impact factor: 5.568

10.  Patient Survey on Satisfaction and Impact of 123I-Ioflupane Dopamine Transporter Imaging.

Authors:  Matthew F Covington; Scott Sherman; Denise Lewis; Hong Lei; Elizabeth Krupinski; Phillip H Kuo
Journal:  PLoS One       Date:  2015-07-30       Impact factor: 3.240

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