Literature DB >> 23514885

CD4 and CD8 T cells directly recognize murine gammaherpesvirus 68-immortalized cells and prevent tumor outgrowth.

Xiaozhan Liang1, Rebecca L Crepeau, Weijun Zhang, Samuel H Speck, Edward J Usherwood.   

Abstract

There has been extensive research regarding T cell recognition of Epstein-Barr virus-transformed cells; however, less is known regarding the recognition of B cells immortalized by gamma-2 herpesviruses. Here we show that B cells immortalized by murine gammaherpesvirus 68 (MHV-68, γHV-68) can be controlled by either CD4 or CD8 T cells in vivo. We present evidence for the direct recognition of infected B cells by CD4 and CD8 T cells. These data will help in the development of immunotherapeutic approaches combating gamma-2 herpesvirus-related disease.

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Mesh：

Year:  2013        PMID： 23514885      PMCID： PMC3648166          DOI： 10.1128/JVI.00375-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  17 in total

1.  CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma.

Authors:  J P Christensen; R D Cardin; K C Branum; P C Doherty
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Cutting edge: activation of virus-specific CD4 T cells throughout γ-herpesvirus latency.

Authors:  Michael L Freeman; Claire E Burkum; Kathleen G Lanzer; Meghan K Jensen; Mushtaq Ahmed; Eric J Yager; Emilio Flaño; Gary M Winslow; David L Woodland; Marcia A Blackman
Journal:  J Immunol       Date:  2011-11-11       Impact factor: 5.422

3.  An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.

Authors:  Rebecca L Sparks-Thissen; Douglas C Braaten; Scott Kreher; Samuel H Speck; Herbert W Virgin
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

4.  CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68.

Authors:  Shinichiro Fuse; Joshua J Obar; Sarah Bellfy; Erica K Leung; Weijun Zhang; Edward J Usherwood
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

5.  Regression of a murine gammaherpesvirus 68-positive b-cell lymphoma mediated by CD4 T lymphocytes.

Authors:  K A Robertson; E J Usherwood; A A Nash
Journal:  J Virol       Date:  2001-04       Impact factor: 5.103

6.  Gammaherpesvirus persistence alters key CD8 T-cell memory characteristics and enhances antiviral protection.

Authors:  Joshua J Obar; Shinichiro Fuse; Erica K Leung; Sarah C Bellfy; Edward J Usherwood
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

7.  Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.

Authors:  K E Weck; A J Dal Canto; J D Gould; A K O'Guin; K A Roth; J E Saffitz; S H Speck; H W Virgin
Journal:  Nat Med       Date:  1997-12       Impact factor: 53.440

8.  Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

Authors:  R D Cardin; J W Brooks; S R Sarawar; P C Doherty
Journal:  J Exp Med       Date:  1996-09-01       Impact factor: 14.307

9.  Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus.

Authors:  Scott A Tibbetts; Linda F van Dyk; Samuel H Speck; Herbert W Virgin
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

10.  Human Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes home preferentially to and induce selective regressions of autologous EBV-induced B cell lymphoproliferations in xenografted C.B-17 scid/scid mice.

Authors:  J F Lacerda; M Ladanyi; D C Louie; J M Fernandez; E B Papadopoulos; R J O'Reilly
Journal:  J Exp Med       Date:  1996-03-01       Impact factor: 14.307
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  7 in total

1.  CD95-CD95L interaction mediates the growth control of MHV68 immortalized B cells by cytotoxic T cells.

Authors:  Sihan Dong; Lingbing Tan; Guifang Chen; Xiaozhen Liang
Journal:  Virol Sin       Date:  2017-06       Impact factor: 4.327

2.  Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection.

Authors:  Ryan N Jennings; Jason M Grayson; Erik S Barton
Journal:  J Virol       Date:  2014-09-24       Impact factor: 5.103

3.  CD95 Signaling Inhibits B Cell Receptor-Mediated Gammaherpesvirus Replication in Apoptosis-Resistant B Lymphoma Cells.

Authors:  Lingbing Tan; Chaocan Zhang; Julien Dematos; Linlin Kuang; Jae U Jung; Xiaozhen Liang
Journal:  J Virol       Date:  2016-10-14       Impact factor: 5.103

4.  CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic.

Authors:  Michael L Freeman; Claire E Burkum; Tres Cookenham; Alan D Roberts; Kathleen G Lanzer; Gail E Huston; Meghan K Jensen; John Sidney; Bjoern Peters; Jacob E Kohlmeier; David L Woodland; Linda F van Dyk; Alessandro Sette; Marcia A Blackman
Journal:  J Immunol       Date:  2014-11-05       Impact factor: 5.422

5.  LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.

Authors:  P T Lange; C N Jondle; E J Darrah; K E Johnson; V L Tarakanova
Journal:  J Virol       Date:  2019-03-05       Impact factor: 5.103

6.  Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.

Authors:  Nicholas K Preiss; Taewook Kang; Young-Kwang Usherwood; Yina H Huang; Bruce R Branchini; Edward J Usherwood
Journal:  J Immunol       Date:  2020-11-13       Impact factor: 5.422

7.  Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2.

Authors:  Brandon Cieniewicz; Nicholas Carpino; Laurie T Krug
Journal:  PLoS One       Date:  2014-02-28       Impact factor: 3.240
  7 in total

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