Literature DB >> 23513721

Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus.

Leonidah Omosa Kerubo1, Jacob Ogweno Midiwo, Solomon Derese, Moses K Langat, Hosea M Akala, Norman C Waters, Martin Peter, Matthias Heydenreich.   

Abstract

From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 microg/mL respectively.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23513721

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  3 in total

Review 1.  The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019.

Authors:  Boris D Bekono; Fidele Ntie-Kang; Pascal Amoa Onguéné; Lydia L Lifongo; Wolfgang Sippl; Karin Fester; Luc C O Owono
Journal:  Malar J       Date:  2020-05-18       Impact factor: 2.979

2.  Antibacterial activities and structure-activity relationships of a panel of 48 compounds from Kenyan plants against multidrug resistant phenotypes.

Authors:  Leonidah K Omosa; Jacob O Midiwo; Armelle T Mbaveng; Simplice B Tankeo; Jackson A Seukep; Igor K Voukeng; Joachim K Dzotam; John Isemeki; Solomon Derese; Ruth A Omolle; Thomas Efferth; Victor Kuete
Journal:  Springerplus       Date:  2016-06-27

3.  Selective Interactions of O-Methylated Flavonoid Natural Products with Human Monoamine Oxidase-A and -B.

Authors:  Narayan D Chaurasiya; Jacob Midiwo; Pankaj Pandey; Regina N Bwire; Robert J Doerksen; Ilias Muhammad; Babu L Tekwani
Journal:  Molecules       Date:  2020-11-17       Impact factor: 4.411
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.