UNLABELLED: Obesity continues to be a major public health problem in the United States and worldwide. While recent statistics have demonstrated that obesity rates have begun to plateau, more severe classes of obesity are accelerating at a faster pace with important implications in regards to treatment. Bariatric surgery has a profound and durable effect on weight loss, being to date one of the most successful interventions for obesity. OBJECTIVE: To provide updates to the possible role of gut hormones in post bariatric surgery weight loss and weight loss maintenance. DESIGN AND METHODS: The current review examines the changes in gastro-intestinal hormones with bariatric surgery and the potential mechanisms by which these changes could result in decreased weight and adiposity. RESULTS: The mechanism by which bariatric surgery results in body weight changes is incompletely elucidated, but it clearly goes beyond caloric restriction and malabsorption. CONCLUSION: Changes in gastro-intestinal hormones, including increases in GLP-1, PYY, and oxyntomodulin, decreases in GIP and ghrelin, or the combined action of all these hormones might play a role in induction and long-term maintenance of weight loss.
UNLABELLED: Obesity continues to be a major public health problem in the United States and worldwide. While recent statistics have demonstrated that obesity rates have begun to plateau, more severe classes of obesity are accelerating at a faster pace with important implications in regards to treatment. Bariatric surgery has a profound and durable effect on weight loss, being to date one of the most successful interventions for obesity. OBJECTIVE: To provide updates to the possible role of gut hormones in post bariatric surgery weight loss and weight loss maintenance. DESIGN AND METHODS: The current review examines the changes in gastro-intestinal hormones with bariatric surgery and the potential mechanisms by which these changes could result in decreased weight and adiposity. RESULTS: The mechanism by which bariatric surgery results in body weight changes is incompletely elucidated, but it clearly goes beyond caloric restriction and malabsorption. CONCLUSION: Changes in gastro-intestinal hormones, including increases in GLP-1, PYY, and oxyntomodulin, decreases in GIP and ghrelin, or the combined action of all these hormones might play a role in induction and long-term maintenance of weight loss.
Authors: Samuel Klein; Elisa Fabbrini; Bruce W Patterson; Kenneth S Polonsky; Carlos A Schiavon; Jose L Correa; Joao E Salles; Bernardo L Wajchenberg; Ricardo Cohen Journal: Obesity (Silver Spring) Date: 2012-01-19 Impact factor: 5.002
Authors: J Kampe; A Stefanidis; S H Lockie; W A Brown; J B Dixon; A Odoi; S J Spencer; J Raven; B J Oldfield Journal: Int J Obes (Lond) Date: 2012-03-27 Impact factor: 5.095
Authors: Ricardo Cohen; Pedro Paulo Caravatto; Jose Luis Correa; Patricia Noujaim; Tarissa Zanata Petry; João Eduardo Salles; Carlos Aurelio Schiavon Journal: Surg Obes Relat Dis Date: 2012-02-02 Impact factor: 4.734
Authors: Dimitri J Pournaras; Clare Glicksman; Royce P Vincent; Shophia Kuganolipava; Jamie Alaghband-Zadeh; David Mahon; Jan H R Bekker; Mohammad A Ghatei; Stephen R Bloom; Julian R F Walters; Richard Welbourn; Carel W le Roux Journal: Endocrinology Date: 2012-06-06 Impact factor: 4.736
Authors: Carmine Finelli; Maria Carmela Padula; Giuseppe Martelli; Giovanni Tarantino Journal: World J Gastroenterol Date: 2014-11-28 Impact factor: 5.742
Authors: Brian Finan; Bin Yang; Nickki Ottaway; David L Smiley; Tao Ma; Christoffer Clemmensen; Joe Chabenne; Lianshan Zhang; Kirk M Habegger; Katrin Fischer; Jonathan E Campbell; Darleen Sandoval; Randy J Seeley; Konrad Bleicher; Sabine Uhles; William Riboulet; Jürgen Funk; Cornelia Hertel; Sara Belli; Elena Sebokova; Karin Conde-Knape; Anish Konkar; Daniel J Drucker; Vasily Gelfanov; Paul T Pfluger; Timo D Müller; Diego Perez-Tilve; Richard D DiMarchi; Matthias H Tschöp Journal: Nat Med Date: 2014-12-08 Impact factor: 53.440